Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

Individuals with Down Syndrome have hematopoietic abnormalities including high risk of leukaemia. Here the authors show that transcriptional silencing of one chromosome 21 by XIST effectively corrects cell function and development to prevent excessive production of megakaryocytes and erythroids, sho...

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Autores principales:	Jen-Chieh Chiang, Jun Jiang, Peter E. Newburger, Jeanne B. Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e64f0d2831c4049891070a7a2eeb202
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spelling	oai:doaj.org-article:5e64f0d2831c4049891070a7a2eeb2022021-12-02T15:33:38ZTrisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro10.1038/s41467-018-07630-y2041-1723https://doaj.org/article/5e64f0d2831c4049891070a7a2eeb2022018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07630-yhttps://doaj.org/toc/2041-1723Individuals with Down Syndrome have hematopoietic abnormalities including high risk of leukaemia. Here the authors show that transcriptional silencing of one chromosome 21 by XIST effectively corrects cell function and development to prevent excessive production of megakaryocytes and erythroids, shown during hematopoietic differentiation of human iPSCs in culture.Jen-Chieh ChiangJun JiangPeter E. NewburgerJeanne B. LawrenceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jen-Chieh Chiang Jun Jiang Peter E. Newburger Jeanne B. Lawrence Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
description	Individuals with Down Syndrome have hematopoietic abnormalities including high risk of leukaemia. Here the authors show that transcriptional silencing of one chromosome 21 by XIST effectively corrects cell function and development to prevent excessive production of megakaryocytes and erythroids, shown during hematopoietic differentiation of human iPSCs in culture.
format	article
author	Jen-Chieh Chiang Jun Jiang Peter E. Newburger Jeanne B. Lawrence
author_facet	Jen-Chieh Chiang Jun Jiang Peter E. Newburger Jeanne B. Lawrence
author_sort	Jen-Chieh Chiang
title	Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
title_short	Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
title_full	Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
title_fullStr	Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
title_full_unstemmed	Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
title_sort	trisomy silencing by xist normalizes down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5e64f0d2831c4049891070a7a2eeb202
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_version_	1718387085347389440

Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro

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