Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

Previously it was shown that an N-terminal tau fragment (NT1) measured in plasma can differentiate individuals with Alzheimer’s disease from healthy controls. Here the authors show that plasma levels of NT1 can associate with future cognitive decline in cognitively normal elderly individuals.

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Autores principales:	Jasmeer P. Chhatwal, Aaron P. Schultz, Yifan Dang, Beth Ostaszewski, Lei Liu, Hyun-Sik Yang, Keith A. Johnson, Reisa A. Sperling, Dennis J. Selkoe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e6552d7e8ff43c699163b028de8f4b4
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spelling	oai:doaj.org-article:5e6552d7e8ff43c699163b028de8f4b42021-12-02T14:40:29ZPlasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals10.1038/s41467-020-19543-w2041-1723https://doaj.org/article/5e6552d7e8ff43c699163b028de8f4b42020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19543-whttps://doaj.org/toc/2041-1723Previously it was shown that an N-terminal tau fragment (NT1) measured in plasma can differentiate individuals with Alzheimer’s disease from healthy controls. Here the authors show that plasma levels of NT1 can associate with future cognitive decline in cognitively normal elderly individuals.Jasmeer P. ChhatwalAaron P. SchultzYifan DangBeth OstaszewskiLei LiuHyun-Sik YangKeith A. JohnsonReisa A. SperlingDennis J. SelkoeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jasmeer P. Chhatwal Aaron P. Schultz Yifan Dang Beth Ostaszewski Lei Liu Hyun-Sik Yang Keith A. Johnson Reisa A. Sperling Dennis J. Selkoe Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
description	Previously it was shown that an N-terminal tau fragment (NT1) measured in plasma can differentiate individuals with Alzheimer’s disease from healthy controls. Here the authors show that plasma levels of NT1 can associate with future cognitive decline in cognitively normal elderly individuals.
format	article
author	Jasmeer P. Chhatwal Aaron P. Schultz Yifan Dang Beth Ostaszewski Lei Liu Hyun-Sik Yang Keith A. Johnson Reisa A. Sperling Dennis J. Selkoe
author_facet	Jasmeer P. Chhatwal Aaron P. Schultz Yifan Dang Beth Ostaszewski Lei Liu Hyun-Sik Yang Keith A. Johnson Reisa A. Sperling Dennis J. Selkoe
author_sort	Jasmeer P. Chhatwal
title	Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
title_short	Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
title_full	Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
title_fullStr	Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
title_full_unstemmed	Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
title_sort	plasma n-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5e6552d7e8ff43c699163b028de8f4b4
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Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

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