Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients

Abstract Sera from candidemic and non-candidemic subjects were examined for antibodies against the cell wall β1,3- and β1,6-glucans, as well as the β-glucan-associated protein MP65 of Candida species. Although antibodies against each of the above components were detected in all subjects, candidemic...

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Autores principales:	Antonella Torosantucci, Mario Tumbarello, Carla Bromuro, Paola Chiani, Brunella Posteraro, Maurizio Sanguinetti, Roberto Cauda, Antonio Cassone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e66eb9a71b040a5b8de927e43e7bebf
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spelling	oai:doaj.org-article:5e66eb9a71b040a5b8de927e43e7bebf2021-12-02T15:06:21ZAntibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients10.1038/s41598-017-02977-62045-2322https://doaj.org/article/5e66eb9a71b040a5b8de927e43e7bebf2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02977-6https://doaj.org/toc/2045-2322Abstract Sera from candidemic and non-candidemic subjects were examined for antibodies against the cell wall β1,3- and β1,6-glucans, as well as the β-glucan-associated protein MP65 of Candida species. Although antibodies against each of the above components were detected in all subjects, candidemic patients had lower antibody titers against β1,3-glucan, but higher antibody titers against β1,6-glucan and MP65, than non-candidemic subjects. The elevated levels of anti-β1,6-glucan and -MP65 antibodies found in candidemic patients were independent on the patient risk category, APACHE II score, presence of co-morbidities, β1,3-glucanemia level, Candida isolate, and antifungal treatment. Interestingly, however, the anti-MP65, but not the anti-β1,6-glucan antibodies, of candidemic patients had higher titers in survivors than in non-survivors, particularly in those subject categories with the highest mortality (>65-years old, diabetic, or septic shock patients). Thus, candidemic patients are capable of boosting anti-Candida immune responses upon infection, and some of these responses might be associated to the generation of protective immunity in patients with candidemia.Antonella TorosantucciMario TumbarelloCarla BromuroPaola ChianiBrunella PosteraroMaurizio SanguinettiRoberto CaudaAntonio CassoneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonella Torosantucci Mario Tumbarello Carla Bromuro Paola Chiani Brunella Posteraro Maurizio Sanguinetti Roberto Cauda Antonio Cassone Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
description	Abstract Sera from candidemic and non-candidemic subjects were examined for antibodies against the cell wall β1,3- and β1,6-glucans, as well as the β-glucan-associated protein MP65 of Candida species. Although antibodies against each of the above components were detected in all subjects, candidemic patients had lower antibody titers against β1,3-glucan, but higher antibody titers against β1,6-glucan and MP65, than non-candidemic subjects. The elevated levels of anti-β1,6-glucan and -MP65 antibodies found in candidemic patients were independent on the patient risk category, APACHE II score, presence of co-morbidities, β1,3-glucanemia level, Candida isolate, and antifungal treatment. Interestingly, however, the anti-MP65, but not the anti-β1,6-glucan antibodies, of candidemic patients had higher titers in survivors than in non-survivors, particularly in those subject categories with the highest mortality (>65-years old, diabetic, or septic shock patients). Thus, candidemic patients are capable of boosting anti-Candida immune responses upon infection, and some of these responses might be associated to the generation of protective immunity in patients with candidemia.
format	article
author	Antonella Torosantucci Mario Tumbarello Carla Bromuro Paola Chiani Brunella Posteraro Maurizio Sanguinetti Roberto Cauda Antonio Cassone
author_facet	Antonella Torosantucci Mario Tumbarello Carla Bromuro Paola Chiani Brunella Posteraro Maurizio Sanguinetti Roberto Cauda Antonio Cassone
author_sort	Antonella Torosantucci
title	Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
title_short	Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
title_full	Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
title_fullStr	Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
title_full_unstemmed	Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients
title_sort	antibodies against a β-glucan-protein complex of candida albicans and its potential as indicator of protective immunity in candidemic patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e66eb9a71b040a5b8de927e43e7bebf
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Antibodies against a β-glucan-protein complex of Candida albicans and its potential as indicator of protective immunity in candidemic patients

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