Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study

Abstract The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rui-fen Zhou, Xiao-Lin Chen, Zhong-guo Zhou, Yao-jun Zhang, Qiu-ye Lan, Gong-cheng Liao, Yu-ming Chen, Hui-lian Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e6a15c1dd51400993179438bf6b5d44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5e6a15c1dd51400993179438bf6b5d44
record_format	dspace
spelling	oai:doaj.org-article:5e6a15c1dd51400993179438bf6b5d442021-12-02T15:05:29ZHigher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study10.1038/s41598-017-00773-w2045-2322https://doaj.org/article/5e6a15c1dd51400993179438bf6b5d442017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00773-whttps://doaj.org/toc/2045-2322Abstract The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency questionnaire were used to collect general information and dietary intake information. Conditional logistic regression showed a significantly inverse association between total choline and betaine intakes and PLC risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for PLC for the top (vs. bottom) tertile were 0.34 (0.24–0.49; P -trend < 0.001) for total choline and 0.67 (0.48–0.93; P -trend = 0.011) for betaine. No significant association was observed between the intake of methionine and PLC risk (P > 0.05). For individual choline compounds, higher consumptions of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin were associated with a lower PLC risk (all P-trend < 0.05). The studied associations were not significantly modified by the folate intake (P-interactions: 0.488–0.890). Our findings suggest that higher choline and betaine intakes may be associated with a lower risk of PLC.Rui-fen ZhouXiao-Lin ChenZhong-guo ZhouYao-jun ZhangQiu-ye LanGong-cheng LiaoYu-ming ChenHui-lian ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rui-fen Zhou Xiao-Lin Chen Zhong-guo Zhou Yao-jun Zhang Qiu-ye Lan Gong-cheng Liao Yu-ming Chen Hui-lian Zhu Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
description	Abstract The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency questionnaire were used to collect general information and dietary intake information. Conditional logistic regression showed a significantly inverse association between total choline and betaine intakes and PLC risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for PLC for the top (vs. bottom) tertile were 0.34 (0.24–0.49; P -trend < 0.001) for total choline and 0.67 (0.48–0.93; P -trend = 0.011) for betaine. No significant association was observed between the intake of methionine and PLC risk (P > 0.05). For individual choline compounds, higher consumptions of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin were associated with a lower PLC risk (all P-trend < 0.05). The studied associations were not significantly modified by the folate intake (P-interactions: 0.488–0.890). Our findings suggest that higher choline and betaine intakes may be associated with a lower risk of PLC.
format	article
author	Rui-fen Zhou Xiao-Lin Chen Zhong-guo Zhou Yao-jun Zhang Qiu-ye Lan Gong-cheng Liao Yu-ming Chen Hui-lian Zhu
author_facet	Rui-fen Zhou Xiao-Lin Chen Zhong-guo Zhou Yao-jun Zhang Qiu-ye Lan Gong-cheng Liao Yu-ming Chen Hui-lian Zhu
author_sort	Rui-fen Zhou
title	Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
title_short	Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
title_full	Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
title_fullStr	Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
title_full_unstemmed	Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
title_sort	higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e6a15c1dd51400993179438bf6b5d44
work_keys_str_mv	AT ruifenzhou higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT xiaolinchen higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT zhongguozhou higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT yaojunzhang higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT qiuyelan higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT gongchengliao higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT yumingchen higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy AT huilianzhu higherdietaryintakesofcholineandbetaineareassociatedwithalowerriskofprimarylivercanceracasecontrolstudy
_version_	1718388832276054016

Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study

Ejemplares similares