Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tub...

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Autores principales: Qin Zhang, Baoling Bai, Xinyu Mei, Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang, Zhigang Wang, Jianxin Wu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie, Li Wang, Zhiyong Qiu, Shiming Zhao, Ting Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/5e6a3aea04a54f029bf8705c5a01523b
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Sumario:Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.

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