Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tub...

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Autores principales:	Qin Zhang, Baoling Bai, Xinyu Mei, Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang, Zhigang Wang, Jianxin Wu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie, Li Wang, Zhiyong Qiu, Shiming Zhao, Ting Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5e6a3aea04a54f029bf8705c5a01523b
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spelling	oai:doaj.org-article:5e6a3aea04a54f029bf8705c5a01523b2021-12-02T15:34:05ZElevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects10.1038/s41467-018-05451-72041-1723https://doaj.org/article/5e6a3aea04a54f029bf8705c5a01523b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05451-7https://doaj.org/toc/2041-1723Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.Qin ZhangBaoling BaiXinyu MeiChunlei WanHaiyan CaoDan LiShan WangMin ZhangZhigang WangJianxin WuHongyan WangJunsheng HuoGangqiang DingJianyuan ZhaoQiu XieLi WangZhiyong QiuShiming ZhaoTing ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qin Zhang Baoling Bai Xinyu Mei Chunlei Wan Haiyan Cao Dan Li Shan Wang Min Zhang Zhigang Wang Jianxin Wu Hongyan Wang Junsheng Huo Gangqiang Ding Jianyuan Zhao Qiu Xie Li Wang Zhiyong Qiu Shiming Zhao Ting Zhang Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
description	Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example Cecr2, Smarca4 and Dnmt3B) linked to neural tube closure.
format	article
author	Qin Zhang Baoling Bai Xinyu Mei Chunlei Wan Haiyan Cao Dan Li Shan Wang Min Zhang Zhigang Wang Jianxin Wu Hongyan Wang Junsheng Huo Gangqiang Ding Jianyuan Zhao Qiu Xie Li Wang Zhiyong Qiu Shiming Zhao Ting Zhang
author_facet	Qin Zhang Baoling Bai Xinyu Mei Chunlei Wan Haiyan Cao Dan Li Shan Wang Min Zhang Zhigang Wang Jianxin Wu Hongyan Wang Junsheng Huo Gangqiang Ding Jianyuan Zhao Qiu Xie Li Wang Zhiyong Qiu Shiming Zhao Ting Zhang
author_sort	Qin Zhang
title	Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
title_short	Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
title_full	Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
title_fullStr	Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
title_full_unstemmed	Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
title_sort	elevated h3k79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5e6a3aea04a54f029bf8705c5a01523b
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Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

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