A temporary indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells

Ex vivo methods of circulating tumor cell (CTC) isolation use small blood volumes, limiting sensitivity and introducing analytical inaccuracies. The authors describe a proof-of-concept study of an in vivo aphaeresis system that continuously collects CTCs from a peripheral vein over several hours.

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Bibliographic Details
Main Authors: Tae Hyun Kim, Yang Wang, C. Ryan Oliver, Douglas H. Thamm, Laura Cooling, Costanza Paoletti, Kaylee J. Smith, Sunitha Nagrath, Daniel F. Hayes
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/5e6e1cbabb7f40a58693713234fb08b1
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Summary:Ex vivo methods of circulating tumor cell (CTC) isolation use small blood volumes, limiting sensitivity and introducing analytical inaccuracies. The authors describe a proof-of-concept study of an in vivo aphaeresis system that continuously collects CTCs from a peripheral vein over several hours.