FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

FKRP mutations cause muscular dystrophies with varied clinical presentations. The target of FKRP is α-dystroglycan, but here the authors show that FKRP also directs sialylation of fibronectin, a process that is essential for recruitment o collagen to the muscle basement membrane.

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Autores principales: A. J. Wood, C. H. Lin, M. Li, K. Nishtala, S. Alaei, F. Rossello, C. Sonntag, L. Hersey, L. B. Miles, C. Krisp, S. Dudczig, A. J. Fulcher, S. Gibertini, P. J. Conroy, A. Siegel, M. Mora, P. Jusuf, N. H. Packer, P. D. Currie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48
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spelling oai:doaj.org-article:5e6f8208fa384dfab7d8162c046eec482021-12-02T15:45:13ZFKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy10.1038/s41467-021-23217-62041-1723https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec482021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23217-6https://doaj.org/toc/2041-1723FKRP mutations cause muscular dystrophies with varied clinical presentations. The target of FKRP is α-dystroglycan, but here the authors show that FKRP also directs sialylation of fibronectin, a process that is essential for recruitment o collagen to the muscle basement membrane.A. J. WoodC. H. LinM. LiK. NishtalaS. AlaeiF. RosselloC. SonntagL. HerseyL. B. MilesC. KrispS. DudczigA. J. FulcherS. GibertiniP. J. ConroyA. SiegelM. MoraP. JusufN. H. PackerP. D. CurrieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
A. J. Wood
C. H. Lin
M. Li
K. Nishtala
S. Alaei
F. Rossello
C. Sonntag
L. Hersey
L. B. Miles
C. Krisp
S. Dudczig
A. J. Fulcher
S. Gibertini
P. J. Conroy
A. Siegel
M. Mora
P. Jusuf
N. H. Packer
P. D. Currie
FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
description FKRP mutations cause muscular dystrophies with varied clinical presentations. The target of FKRP is α-dystroglycan, but here the authors show that FKRP also directs sialylation of fibronectin, a process that is essential for recruitment o collagen to the muscle basement membrane.
format article
author A. J. Wood
C. H. Lin
M. Li
K. Nishtala
S. Alaei
F. Rossello
C. Sonntag
L. Hersey
L. B. Miles
C. Krisp
S. Dudczig
A. J. Fulcher
S. Gibertini
P. J. Conroy
A. Siegel
M. Mora
P. Jusuf
N. H. Packer
P. D. Currie
author_facet A. J. Wood
C. H. Lin
M. Li
K. Nishtala
S. Alaei
F. Rossello
C. Sonntag
L. Hersey
L. B. Miles
C. Krisp
S. Dudczig
A. J. Fulcher
S. Gibertini
P. J. Conroy
A. Siegel
M. Mora
P. Jusuf
N. H. Packer
P. D. Currie
author_sort A. J. Wood
title FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
title_short FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
title_full FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
title_fullStr FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
title_full_unstemmed FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
title_sort fkrp-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48
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