FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

FKRP mutations cause muscular dystrophies with varied clinical presentations. The target of FKRP is α-dystroglycan, but here the authors show that FKRP also directs sialylation of fibronectin, a process that is essential for recruitment o collagen to the muscle basement membrane.

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Auteurs principaux: A. J. Wood, C. H. Lin, M. Li, K. Nishtala, S. Alaei, F. Rossello, C. Sonntag, L. Hersey, L. B. Miles, C. Krisp, S. Dudczig, A. J. Fulcher, S. Gibertini, P. J. Conroy, A. Siegel, M. Mora, P. Jusuf, N. H. Packer, P. D. Currie
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48
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https://doaj.org/article/5e6f8208fa384dfab7d8162c046eec48

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