Impact of persistent D-dimer elevation following recovery from COVID-19

<h4>Background</h4> Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia. <h4>Objectives</h4> To e...

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Autores principales:	Antje Lehmann, Helmut Prosch, Sonja Zehetmayer, Maximilian Robert Gysan, Dominik Bernitzky, Karin Vonbank, Marco Idzko, Daniela Gompelmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e702c4115e54d7b9c96b1af17347cfa
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spelling	oai:doaj.org-article:5e702c4115e54d7b9c96b1af17347cfa2021-11-04T06:49:34ZImpact of persistent D-dimer elevation following recovery from COVID-191932-6203https://doaj.org/article/5e702c4115e54d7b9c96b1af17347cfa2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553152/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia. <h4>Objectives</h4> To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19. <h4>Methods</h4> In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level. <h4>Results</h4> 129 patients (median age 48.8 years; range 19–91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64–130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33). <h4>Conclusion</h4> In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.Antje LehmannHelmut ProschSonja ZehetmayerMaximilian Robert GysanDominik BernitzkyKarin VonbankMarco IdzkoDaniela GompelmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann Impact of persistent D-dimer elevation following recovery from COVID-19
description	<h4>Background</h4> Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia. <h4>Objectives</h4> To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19. <h4>Methods</h4> In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level. <h4>Results</h4> 129 patients (median age 48.8 years; range 19–91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64–130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33). <h4>Conclusion</h4> In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.
format	article
author	Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann
author_facet	Antje Lehmann Helmut Prosch Sonja Zehetmayer Maximilian Robert Gysan Dominik Bernitzky Karin Vonbank Marco Idzko Daniela Gompelmann
author_sort	Antje Lehmann
title	Impact of persistent D-dimer elevation following recovery from COVID-19
title_short	Impact of persistent D-dimer elevation following recovery from COVID-19
title_full	Impact of persistent D-dimer elevation following recovery from COVID-19
title_fullStr	Impact of persistent D-dimer elevation following recovery from COVID-19
title_full_unstemmed	Impact of persistent D-dimer elevation following recovery from COVID-19
title_sort	impact of persistent d-dimer elevation following recovery from covid-19
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5e702c4115e54d7b9c96b1af17347cfa
work_keys_str_mv	AT antjelehmann impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT helmutprosch impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT sonjazehetmayer impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT maximilianrobertgysan impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT dominikbernitzky impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT karinvonbank impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT marcoidzko impactofpersistentddimerelevationfollowingrecoveryfromcovid19 AT danielagompelmann impactofpersistentddimerelevationfollowingrecoveryfromcovid19
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Impact of persistent D-dimer elevation following recovery from COVID-19

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