Vascular Dysfunction in Preeclampsia

Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preecla...

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Autores principales:	Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	preeclampsia pregnancy gestation hypertension vessel blood pressure Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5e72f90fd76043b9b599367b8881060e
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spelling	oai:doaj.org-article:5e72f90fd76043b9b599367b8881060e2021-11-25T17:10:53ZVascular Dysfunction in Preeclampsia10.3390/cells101130552073-4409https://doaj.org/article/5e72f90fd76043b9b599367b8881060e2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3055https://doaj.org/toc/2073-4409Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete spiral artery remodeling, and endothelial damage, which are further propagated by immune factors, mitochondrial stress, and an imbalance of pro- and antiangiogenic substances. While the field has progressed, current gaps in knowledge include detailed initial molecular mechanisms and effective treatment options. Newfound evidence indicates that vasopressin is an early mediator and biomarker of the disorder, and promising future therapeutic avenues include mitigating mitochondrial dysfunction, excess oxidative stress, and the resulting inflammatory state. In this review, we provide a detailed overview of vascular defects present during preeclampsia and connect well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels.Megan A. OpichkaMatthew W. RappeltDavid D. GuttermanJustin L. GrobeJennifer J. McIntoshMDPI AGarticlepreeclampsiapregnancygestationhypertensionvesselblood pressureBiology (General)QH301-705.5ENCells, Vol 10, Iss 3055, p 3055 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	preeclampsia pregnancy gestation hypertension vessel blood pressure Biology (General) QH301-705.5
spellingShingle	preeclampsia pregnancy gestation hypertension vessel blood pressure Biology (General) QH301-705.5 Megan A. Opichka Matthew W. Rappelt David D. Gutterman Justin L. Grobe Jennifer J. McIntosh Vascular Dysfunction in Preeclampsia
description	Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact underlying cause is not precisely defined and likely heterogenous, a plethora of research indicates that in some women with preeclampsia, both maternal and placental vascular dysfunction plays a role in the pathogenesis and can persist into the postpartum period. Potential abnormalities include impaired placentation, incomplete spiral artery remodeling, and endothelial damage, which are further propagated by immune factors, mitochondrial stress, and an imbalance of pro- and antiangiogenic substances. While the field has progressed, current gaps in knowledge include detailed initial molecular mechanisms and effective treatment options. Newfound evidence indicates that vasopressin is an early mediator and biomarker of the disorder, and promising future therapeutic avenues include mitigating mitochondrial dysfunction, excess oxidative stress, and the resulting inflammatory state. In this review, we provide a detailed overview of vascular defects present during preeclampsia and connect well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels.
format	article
author	Megan A. Opichka Matthew W. Rappelt David D. Gutterman Justin L. Grobe Jennifer J. McIntosh
author_facet	Megan A. Opichka Matthew W. Rappelt David D. Gutterman Justin L. Grobe Jennifer J. McIntosh
author_sort	Megan A. Opichka
title	Vascular Dysfunction in Preeclampsia
title_short	Vascular Dysfunction in Preeclampsia
title_full	Vascular Dysfunction in Preeclampsia
title_fullStr	Vascular Dysfunction in Preeclampsia
title_full_unstemmed	Vascular Dysfunction in Preeclampsia
title_sort	vascular dysfunction in preeclampsia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5e72f90fd76043b9b599367b8881060e
work_keys_str_mv	AT meganaopichka vasculardysfunctioninpreeclampsia AT matthewwrappelt vasculardysfunctioninpreeclampsia AT daviddgutterman vasculardysfunctioninpreeclampsia AT justinlgrobe vasculardysfunctioninpreeclampsia AT jenniferjmcintosh vasculardysfunctioninpreeclampsia
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Vascular Dysfunction in Preeclampsia

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