Biomimetic heterogenous elastic tissue development

3D Printing Artificial Elastic Tissues Solvent-free thermoplastic polyurethanes (TPU) could be used to 3D-print artificial tissues saving time and money. Achala de Mel and colleagues at University College London used open-source 3D-modelling software and commercially available 3D printers to fabrica...

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Autores principales:	Kai Jen Tsai, Simon Dixon, Luke Richard Hale, Arnold Darbyshire, Daniel Martin, Achala de Mel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/5e77206a1a7e4dd6abd4569363a3bb37
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id	oai:doaj.org-article:5e77206a1a7e4dd6abd4569363a3bb37
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spelling	oai:doaj.org-article:5e77206a1a7e4dd6abd4569363a3bb372021-12-02T14:22:14ZBiomimetic heterogenous elastic tissue development10.1038/s41536-017-0021-42057-3995https://doaj.org/article/5e77206a1a7e4dd6abd4569363a3bb372017-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0021-4https://doaj.org/toc/2057-39953D Printing Artificial Elastic Tissues Solvent-free thermoplastic polyurethanes (TPU) could be used to 3D-print artificial tissues saving time and money. Achala de Mel and colleagues at University College London used open-source 3D-modelling software and commercially available 3D printers to fabricate a bespoke tracheal stent from custom-made TPU. The team was able to control the material’s porosity with 3D-design, which could facilitate its vascularisation if implanted. The trachea was mechanically and structurally similar to that of an adult, showing longitudinal elasticity and radial rigidity. When attached to a ventilator system, it responded well to pressures similar to those of inspiration, forced expiration, coughing or crying. 3D-printed trachea was treated with bioactive molecules so cells could potentially adhere to and proliferate on its surface. This method could be used to fabricate bespoke elastic tissue substitutes, avoiding costly and time-consuming cell-culture techniques.Kai Jen TsaiSimon DixonLuke Richard HaleArnold DarbyshireDaniel MartinAchala de MelNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Kai Jen Tsai Simon Dixon Luke Richard Hale Arnold Darbyshire Daniel Martin Achala de Mel Biomimetic heterogenous elastic tissue development
description	3D Printing Artificial Elastic Tissues Solvent-free thermoplastic polyurethanes (TPU) could be used to 3D-print artificial tissues saving time and money. Achala de Mel and colleagues at University College London used open-source 3D-modelling software and commercially available 3D printers to fabricate a bespoke tracheal stent from custom-made TPU. The team was able to control the material’s porosity with 3D-design, which could facilitate its vascularisation if implanted. The trachea was mechanically and structurally similar to that of an adult, showing longitudinal elasticity and radial rigidity. When attached to a ventilator system, it responded well to pressures similar to those of inspiration, forced expiration, coughing or crying. 3D-printed trachea was treated with bioactive molecules so cells could potentially adhere to and proliferate on its surface. This method could be used to fabricate bespoke elastic tissue substitutes, avoiding costly and time-consuming cell-culture techniques.
format	article
author	Kai Jen Tsai Simon Dixon Luke Richard Hale Arnold Darbyshire Daniel Martin Achala de Mel
author_facet	Kai Jen Tsai Simon Dixon Luke Richard Hale Arnold Darbyshire Daniel Martin Achala de Mel
author_sort	Kai Jen Tsai
title	Biomimetic heterogenous elastic tissue development
title_short	Biomimetic heterogenous elastic tissue development
title_full	Biomimetic heterogenous elastic tissue development
title_fullStr	Biomimetic heterogenous elastic tissue development
title_full_unstemmed	Biomimetic heterogenous elastic tissue development
title_sort	biomimetic heterogenous elastic tissue development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e77206a1a7e4dd6abd4569363a3bb37
work_keys_str_mv	AT kaijentsai biomimeticheterogenouselastictissuedevelopment AT simondixon biomimeticheterogenouselastictissuedevelopment AT lukerichardhale biomimeticheterogenouselastictissuedevelopment AT arnolddarbyshire biomimeticheterogenouselastictissuedevelopment AT danielmartin biomimeticheterogenouselastictissuedevelopment AT achalademel biomimeticheterogenouselastictissuedevelopment
_version_	1718391488588546048

Biomimetic heterogenous elastic tissue development

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