Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

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Bibliographic Details
Main Authors:	Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman, Anne Spang
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d73484
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spelling	oai:doaj.org-article:5e7eddb79b0041a6b55bc4fe25d734842021-12-02T16:43:43ZPatched regulates lipid homeostasis by controlling cellular cholesterol levels10.1038/s41467-021-24995-92041-1723https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d734842021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24995-9https://doaj.org/toc/2041-1723Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.Carla E. Cadena del CastilloJ. Thomas HannichAndres KaechHirohisa ChiyodaJonathan BrewerMasamitsu FukuyamaNils J. FærgemanHoward RiezmanAnne SpangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carla E. Cadena del Castillo J. Thomas Hannich Andres Kaech Hirohisa Chiyoda Jonathan Brewer Masamitsu Fukuyama Nils J. Færgeman Howard Riezman Anne Spang Patched regulates lipid homeostasis by controlling cellular cholesterol levels
description	Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.
format	article
author	Carla E. Cadena del Castillo J. Thomas Hannich Andres Kaech Hirohisa Chiyoda Jonathan Brewer Masamitsu Fukuyama Nils J. Færgeman Howard Riezman Anne Spang
author_facet	Carla E. Cadena del Castillo J. Thomas Hannich Andres Kaech Hirohisa Chiyoda Jonathan Brewer Masamitsu Fukuyama Nils J. Færgeman Howard Riezman Anne Spang
author_sort	Carla E. Cadena del Castillo
title	Patched regulates lipid homeostasis by controlling cellular cholesterol levels
title_short	Patched regulates lipid homeostasis by controlling cellular cholesterol levels
title_full	Patched regulates lipid homeostasis by controlling cellular cholesterol levels
title_fullStr	Patched regulates lipid homeostasis by controlling cellular cholesterol levels
title_full_unstemmed	Patched regulates lipid homeostasis by controlling cellular cholesterol levels
title_sort	patched regulates lipid homeostasis by controlling cellular cholesterol levels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d73484
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Patched regulates lipid homeostasis by controlling cellular cholesterol levels

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