Multiple random phosphorylations in clock proteins provide long delays and switches

Abstract Theory predicts that self-sustained oscillations require robust delays and nonlinearities (ultrasensitivity). Delayed negative feedback loops with switch-like inhibition of transcription constitute the core of eukaryotic circadian clocks. The kinetics of core clock proteins such as PER2 in...

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Autores principales: Abhishek Upadhyay, Daniela Marzoll, Axel Diernfellner, Michael Brunner, Hanspeter Herzel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5e843467c919438490c8149ced74124a
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