Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains

Abstract Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24...

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Autores principales:	Li-Kuang Chen, Shu-Chen Kuo, Kai-Chih Chang, Chieh-Chen Cheng, Pei-Ying Yu, Chih-Hui Chang, Tren-Yi Chen, Chun-Chieh Tseng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e87a8947bda45078a5a831f14ef6e76
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spelling	oai:doaj.org-article:5e87a8947bda45078a5a831f14ef6e762021-12-02T12:32:34ZClinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains10.1038/s41598-017-06688-w2045-2322https://doaj.org/article/5e87a8947bda45078a5a831f14ef6e762017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06688-whttps://doaj.org/toc/2045-2322Abstract Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting A. baumannii were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of A. baumannii to different phages were compared. In our study, a total of 403 clinically isolated A. baumannii strains were identified. On average, the phage infection percentage of the antibiotic-resistant A. baumannii strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive A. baumannii strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for A. baumannii was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response (p-trend < 0.0001). Among all of the A. baumannii isolates, 75.6% were phage typeable. The results of phage typing might also reveal the antibiotic-resistant profiles of clinical A. baumannii strains. In conclusion, phage susceptibility represents an evolutionary trade-off in A. baumannii strains that show adaptations for antibiotic resistance, particularly in medical environments that have high antibiotic use.Li-Kuang ChenShu-Chen KuoKai-Chih ChangChieh-Chen ChengPei-Ying YuChih-Hui ChangTren-Yi ChenChun-Chieh TsengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Kuang Chen Shu-Chen Kuo Kai-Chih Chang Chieh-Chen Cheng Pei-Ying Yu Chih-Hui Chang Tren-Yi Chen Chun-Chieh Tseng Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
description	Abstract Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting A. baumannii were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of A. baumannii to different phages were compared. In our study, a total of 403 clinically isolated A. baumannii strains were identified. On average, the phage infection percentage of the antibiotic-resistant A. baumannii strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive A. baumannii strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for A. baumannii was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response (p-trend < 0.0001). Among all of the A. baumannii isolates, 75.6% were phage typeable. The results of phage typing might also reveal the antibiotic-resistant profiles of clinical A. baumannii strains. In conclusion, phage susceptibility represents an evolutionary trade-off in A. baumannii strains that show adaptations for antibiotic resistance, particularly in medical environments that have high antibiotic use.
format	article
author	Li-Kuang Chen Shu-Chen Kuo Kai-Chih Chang Chieh-Chen Cheng Pei-Ying Yu Chih-Hui Chang Tren-Yi Chen Chun-Chieh Tseng
author_facet	Li-Kuang Chen Shu-Chen Kuo Kai-Chih Chang Chieh-Chen Cheng Pei-Ying Yu Chih-Hui Chang Tren-Yi Chen Chun-Chieh Tseng
author_sort	Li-Kuang Chen
title	Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
title_short	Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
title_full	Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
title_fullStr	Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
title_full_unstemmed	Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains
title_sort	clinical antibiotic-resistant acinetobacter baumannii strains with higher susceptibility to environmental phages than antibiotic-sensitive strains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e87a8947bda45078a5a831f14ef6e76
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Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains

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