Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences

Ewa Kruszyńska,1 Maria Łoboz-Rudnicka,1 Carlo Palombo,2 Olga Vriz,3 Michaela Kozakova,4 Bogusława Ołpińska,1 Carmela Morizzo,2 Krystyna Łoboz-Grudzień,1,5 Joanna Jaroch1,5 1Cardiology Department, T. Marciniak Hospital, Emergency Medicine Center, Wrocław, Poland; 2Department of Surgical, Medical and...

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Autores principales:	Kruszyńska E, Łoboz-Rudnicka M, Palombo C, Vriz O, Kozakova M, Ołpińska B, Morizzo C, Łoboz-Grudzień K, Jaroch J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	carotid artery stiffness metabolic syndrome sex differences Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5e8c0f72a4534d489794b90963ada852
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spelling	oai:doaj.org-article:5e8c0f72a4534d489794b90963ada8522021-12-02T13:04:02ZCarotid Artery Stiffness in Metabolic Syndrome: Sex Differences1178-7007https://doaj.org/article/5e8c0f72a4534d489794b90963ada8522020-09-01T00:00:00Zhttps://www.dovepress.com/carotid-artery-stiffness-in-metabolic-syndrome-sex-differences-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ewa Kruszyńska,1 Maria Łoboz-Rudnicka,1 Carlo Palombo,2 Olga Vriz,3 Michaela Kozakova,4 Bogusława Ołpińska,1 Carmela Morizzo,2 Krystyna Łoboz-Grudzień,1,5 Joanna Jaroch1,5 1Cardiology Department, T. Marciniak Hospital, Emergency Medicine Center, Wrocław, Poland; 2Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, School of Medicine, Pisa, Italy; 3Department of Cardiology and Emergency, San Antonio Hospital, Udine, Italy; 4Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 5Faculty of Health Sciences, Wrocław Medical University, Wrocław, PolandCorrespondence: Maria Łoboz-Rudnicka Email marialoboz@o2.plIntroduction: The effect of metabolic syndrome (MS) on carotid stiffness (CS) in the context of gender is under research.Objective: We examined the relationship between the MS and CS in men (M) and women (W) and investigated if the impact of cardiovascular risk factors on CS is modulated by gender.Patients and Methods: The study included 419 subjects (mean age 54.3 years): 215 (51%) with MS (109 W and 106 M) and 204 (49%) without MS (98 W and 106 M). Carotid intima-media thickness (IMT) and CS parameters (beta stiffness index (beta), Peterson’s elastic modulus (Ep), arterial compliance (AC) and one-point pulse wave velocity (PWV-beta)) were measured with the echo-tracking (eT) system.Results: ANCOVA demonstrated that MS was associated with elevated CS indices (p = 0.003 for beta and 0.025 for PWV-beta), although further sex-specific analysis revealed that this relationship was significant only in W (p = 0.021 for beta). Age was associated with CS in both M and W, pulse pressure (PP) and body mass index turned out to be determinants of CS solely in W, while the effect of mean arterial pressure (MAP) and heart rate was more pronounced in M. MANOVA performed in subjects with MS revealed that age and diabetes mellitus type 2 were determinants of CS in both sexes, diastolic blood pressure and MAP – solely in M and systolic blood pressure, PP and waist circumference – solely in W (the relationship between the waist circumference and AC was paradoxical).Conclusion: The relationship between MS and CS is stronger in W than in M. In subjects with MS, various components of arterial pressure exert different sex-specific effects on CS – with the impact of the pulsative component of arterial pressure (PP) observed in W and the impact of the steady component (MAP) observed in M.Keywords: carotid artery stiffness, metabolic syndrome, sex differencesKruszyńska EŁoboz-Rudnicka MPalombo CVriz OKozakova MOłpińska BMorizzo CŁoboz-Grudzień KJaroch JDove Medical Pressarticlecarotid artery stiffnessmetabolic syndromesex differencesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3359-3369 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	carotid artery stiffness metabolic syndrome sex differences Specialties of internal medicine RC581-951
spellingShingle	carotid artery stiffness metabolic syndrome sex differences Specialties of internal medicine RC581-951 Kruszyńska E Łoboz-Rudnicka M Palombo C Vriz O Kozakova M Ołpińska B Morizzo C Łoboz-Grudzień K Jaroch J Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
description	Ewa Kruszyńska,1 Maria Łoboz-Rudnicka,1 Carlo Palombo,2 Olga Vriz,3 Michaela Kozakova,4 Bogusława Ołpińska,1 Carmela Morizzo,2 Krystyna Łoboz-Grudzień,1,5 Joanna Jaroch1,5 1Cardiology Department, T. Marciniak Hospital, Emergency Medicine Center, Wrocław, Poland; 2Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, School of Medicine, Pisa, Italy; 3Department of Cardiology and Emergency, San Antonio Hospital, Udine, Italy; 4Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 5Faculty of Health Sciences, Wrocław Medical University, Wrocław, PolandCorrespondence: Maria Łoboz-Rudnicka Email marialoboz@o2.plIntroduction: The effect of metabolic syndrome (MS) on carotid stiffness (CS) in the context of gender is under research.Objective: We examined the relationship between the MS and CS in men (M) and women (W) and investigated if the impact of cardiovascular risk factors on CS is modulated by gender.Patients and Methods: The study included 419 subjects (mean age 54.3 years): 215 (51%) with MS (109 W and 106 M) and 204 (49%) without MS (98 W and 106 M). Carotid intima-media thickness (IMT) and CS parameters (beta stiffness index (beta), Peterson’s elastic modulus (Ep), arterial compliance (AC) and one-point pulse wave velocity (PWV-beta)) were measured with the echo-tracking (eT) system.Results: ANCOVA demonstrated that MS was associated with elevated CS indices (p = 0.003 for beta and 0.025 for PWV-beta), although further sex-specific analysis revealed that this relationship was significant only in W (p = 0.021 for beta). Age was associated with CS in both M and W, pulse pressure (PP) and body mass index turned out to be determinants of CS solely in W, while the effect of mean arterial pressure (MAP) and heart rate was more pronounced in M. MANOVA performed in subjects with MS revealed that age and diabetes mellitus type 2 were determinants of CS in both sexes, diastolic blood pressure and MAP – solely in M and systolic blood pressure, PP and waist circumference – solely in W (the relationship between the waist circumference and AC was paradoxical).Conclusion: The relationship between MS and CS is stronger in W than in M. In subjects with MS, various components of arterial pressure exert different sex-specific effects on CS – with the impact of the pulsative component of arterial pressure (PP) observed in W and the impact of the steady component (MAP) observed in M.Keywords: carotid artery stiffness, metabolic syndrome, sex differences
format	article
author	Kruszyńska E Łoboz-Rudnicka M Palombo C Vriz O Kozakova M Ołpińska B Morizzo C Łoboz-Grudzień K Jaroch J
author_facet	Kruszyńska E Łoboz-Rudnicka M Palombo C Vriz O Kozakova M Ołpińska B Morizzo C Łoboz-Grudzień K Jaroch J
author_sort	Kruszyńska E
title	Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
title_short	Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
title_full	Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
title_fullStr	Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
title_full_unstemmed	Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences
title_sort	carotid artery stiffness in metabolic syndrome: sex differences
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5e8c0f72a4534d489794b90963ada852
work_keys_str_mv	AT kruszynskae carotidarterystiffnessinmetabolicsyndromesexdifferences AT łobozrudnickam carotidarterystiffnessinmetabolicsyndromesexdifferences AT palomboc carotidarterystiffnessinmetabolicsyndromesexdifferences AT vrizo carotidarterystiffnessinmetabolicsyndromesexdifferences AT kozakovam carotidarterystiffnessinmetabolicsyndromesexdifferences AT ołpinskab carotidarterystiffnessinmetabolicsyndromesexdifferences AT morizzoc carotidarterystiffnessinmetabolicsyndromesexdifferences AT łobozgrudzienk carotidarterystiffnessinmetabolicsyndromesexdifferences AT jarochj carotidarterystiffnessinmetabolicsyndromesexdifferences
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Carotid Artery Stiffness in Metabolic Syndrome: Sex Differences

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