Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.

The recent detection and isolation of C. ureolyticus from patients with diarrhoeal illness and inflammatory bowel diseases warrants further investigation into its role as an emerging pathogen of the human gastrointestinal tract. Regarding the pathogenic mechanisms employed by this species we provide...

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Autores principales:	Susan Bullman, Alan Lucid, Daniel Corcoran, Roy D Sleator, Brigid Lucey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e8fa512f9884b0c80424acee2db4a77
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spelling	oai:doaj.org-article:5e8fa512f9884b0c80424acee2db4a772021-11-18T08:57:39ZGenomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.1932-620310.1371/journal.pone.0071515https://doaj.org/article/5e8fa512f9884b0c80424acee2db4a772013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023611/?tool=EBIhttps://doaj.org/toc/1932-6203The recent detection and isolation of C. ureolyticus from patients with diarrhoeal illness and inflammatory bowel diseases warrants further investigation into its role as an emerging pathogen of the human gastrointestinal tract. Regarding the pathogenic mechanisms employed by this species we provide the first whole genome analysis of two C. ureolyticus isolates including the type strain. Comparative analysis, subtractive hybridisation and gene ontology searches against other Campylobacter species identifies the high degree of heterogenicity between C. ureolyticus isolates, in addition to the identification of 106 putative virulence associated factors, 52 of which are predicted to be secreted. Such factors encompass each of the known virulence tactics of pathogenic Campylobacter spp. including adhesion and colonisation (CadF, PEB1, IcmF and FlpA), invasion (ciaB and 16 virB-virD4 genes) and toxin production (S-layer RTX and ZOT). Herein, we provide the first virulence catalogue for C. ureolyticus, the components of which theoretically provide this emerging species with sufficient arsenal to establish pathology.Susan BullmanAlan LucidDaniel CorcoranRoy D SleatorBrigid LuceyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71515 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susan Bullman Alan Lucid Daniel Corcoran Roy D Sleator Brigid Lucey Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
description	The recent detection and isolation of C. ureolyticus from patients with diarrhoeal illness and inflammatory bowel diseases warrants further investigation into its role as an emerging pathogen of the human gastrointestinal tract. Regarding the pathogenic mechanisms employed by this species we provide the first whole genome analysis of two C. ureolyticus isolates including the type strain. Comparative analysis, subtractive hybridisation and gene ontology searches against other Campylobacter species identifies the high degree of heterogenicity between C. ureolyticus isolates, in addition to the identification of 106 putative virulence associated factors, 52 of which are predicted to be secreted. Such factors encompass each of the known virulence tactics of pathogenic Campylobacter spp. including adhesion and colonisation (CadF, PEB1, IcmF and FlpA), invasion (ciaB and 16 virB-virD4 genes) and toxin production (S-layer RTX and ZOT). Herein, we provide the first virulence catalogue for C. ureolyticus, the components of which theoretically provide this emerging species with sufficient arsenal to establish pathology.
format	article
author	Susan Bullman Alan Lucid Daniel Corcoran Roy D Sleator Brigid Lucey
author_facet	Susan Bullman Alan Lucid Daniel Corcoran Roy D Sleator Brigid Lucey
author_sort	Susan Bullman
title	Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
title_short	Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
title_full	Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
title_fullStr	Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
title_full_unstemmed	Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.
title_sort	genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen campylobacter ureolyticus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5e8fa512f9884b0c80424acee2db4a77
work_keys_str_mv	AT susanbullman genomicinvestigationintostrainheterogeneityandpathogenicpotentialoftheemerginggastrointestinalpathogencampylobacterureolyticus AT alanlucid genomicinvestigationintostrainheterogeneityandpathogenicpotentialoftheemerginggastrointestinalpathogencampylobacterureolyticus AT danielcorcoran genomicinvestigationintostrainheterogeneityandpathogenicpotentialoftheemerginggastrointestinalpathogencampylobacterureolyticus AT roydsleator genomicinvestigationintostrainheterogeneityandpathogenicpotentialoftheemerginggastrointestinalpathogencampylobacterureolyticus AT brigidlucey genomicinvestigationintostrainheterogeneityandpathogenicpotentialoftheemerginggastrointestinalpathogencampylobacterureolyticus
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Genomic investigation into strain heterogeneity and pathogenic potential of the emerging gastrointestinal pathogen Campylobacter ureolyticus.

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