Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains

Abstract Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by Gd CA can be converted into resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of the Gd CA in the brain i...

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Autores principales:	Clémence Dudeffant, Matthias Vandesquille, Kelly Herbert, Clément M. Garin, Sandro Alves, Véronique Blanchard, Emmanuel E. Comoy, Fanny Petit, Marc Dhenain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e93a4a65928455e9bb7593b8b3d98c9
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spelling	oai:doaj.org-article:5e93a4a65928455e9bb7593b8b3d98c92021-12-02T12:32:51ZContrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains10.1038/s41598-017-05285-12045-2322https://doaj.org/article/5e93a4a65928455e9bb7593b8b3d98c92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05285-1https://doaj.org/toc/2045-2322Abstract Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by Gd CA can be converted into resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of the Gd CA in the brain improves the contrast between different tissues and provides new contrasts in MR images. Gd-stained MRI detects amyloid plaques, one of the microscopic lesions of Alzheimer’s disease (AD), in APPSL/PS1M146L mice or in primates. Numerous transgenic mice with various plaque typologies have been developed to mimic cerebral amyloidosis and comparison of plaque detection between animal models and humans with new imaging methods is a recurrent concern. Here, we investigated detection of amyloid plaques by Gd-stained MRI in five mouse models of amyloidosis (APPSL/PS1M146L, APP/PS1dE9, APP23, APPSwDI, and 3xTg) presenting with compact, diffuse and intracellular plaques as well as in post mortem human-AD brains. The brains were then evaluated by histology to investigate the impact of size, compactness, and iron load of amyloid plaques on their detection by MRI. We show that Gd-stained MRI allows detection of compact amyloid plaques as small as 25 µm, independently of their iron load, in mice as well as in human-AD brains.Clémence DudeffantMatthias VandesquilleKelly HerbertClément M. GarinSandro AlvesVéronique BlanchardEmmanuel E. ComoyFanny PetitMarc DhenainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clémence Dudeffant Matthias Vandesquille Kelly Herbert Clément M. Garin Sandro Alves Véronique Blanchard Emmanuel E. Comoy Fanny Petit Marc Dhenain Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
description	Abstract Gadolinium (Gd)-stained MRI is based on Gd contrast agent (CA) administration into the brain parenchyma. The strong signal increase induced by Gd CA can be converted into resolution enhancement to record microscopic MR images. Moreover, inhomogeneous distribution of the Gd CA in the brain improves the contrast between different tissues and provides new contrasts in MR images. Gd-stained MRI detects amyloid plaques, one of the microscopic lesions of Alzheimer’s disease (AD), in APPSL/PS1M146L mice or in primates. Numerous transgenic mice with various plaque typologies have been developed to mimic cerebral amyloidosis and comparison of plaque detection between animal models and humans with new imaging methods is a recurrent concern. Here, we investigated detection of amyloid plaques by Gd-stained MRI in five mouse models of amyloidosis (APPSL/PS1M146L, APP/PS1dE9, APP23, APPSwDI, and 3xTg) presenting with compact, diffuse and intracellular plaques as well as in post mortem human-AD brains. The brains were then evaluated by histology to investigate the impact of size, compactness, and iron load of amyloid plaques on their detection by MRI. We show that Gd-stained MRI allows detection of compact amyloid plaques as small as 25 µm, independently of their iron load, in mice as well as in human-AD brains.
format	article
author	Clémence Dudeffant Matthias Vandesquille Kelly Herbert Clément M. Garin Sandro Alves Véronique Blanchard Emmanuel E. Comoy Fanny Petit Marc Dhenain
author_facet	Clémence Dudeffant Matthias Vandesquille Kelly Herbert Clément M. Garin Sandro Alves Véronique Blanchard Emmanuel E. Comoy Fanny Petit Marc Dhenain
author_sort	Clémence Dudeffant
title	Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
title_short	Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
title_full	Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
title_fullStr	Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
title_full_unstemmed	Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains
title_sort	contrast-enhanced mr microscopy of amyloid plaques in five mouse models of amyloidosis and in human alzheimer’s disease brains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e93a4a65928455e9bb7593b8b3d98c9
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Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer’s disease brains

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