Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction

Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-st...

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Autores principales: Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine, Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825b
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spelling oai:doaj.org-article:5e96ad72a7fc4e428e30cd13deb2825b2021-12-02T16:30:42ZXbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction10.1038/s41467-021-21931-92041-1723https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21931-9https://doaj.org/toc/2041-1723Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.Gabriele G. SchiattarellaFrancisco AltamiranoSoo Young KimDan TongAnwarul FerdousHande PiristineSubhajit DasguptaXuliang WangKristin M. FrenchElisa VillalobosStephen B. SpurginMaayan WaldmanNan JiangHerman I. MayTheodore M. HillYuxuan LuoHeesoo YooVlad G. ZahaSergio LavanderoThomas G. GilletteJoseph A. HillNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gabriele G. Schiattarella
Francisco Altamirano
Soo Young Kim
Dan Tong
Anwarul Ferdous
Hande Piristine
Subhajit Dasgupta
Xuliang Wang
Kristin M. French
Elisa Villalobos
Stephen B. Spurgin
Maayan Waldman
Nan Jiang
Herman I. May
Theodore M. Hill
Yuxuan Luo
Heesoo Yoo
Vlad G. Zaha
Sergio Lavandero
Thomas G. Gillette
Joseph A. Hill
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
description Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.
format article
author Gabriele G. Schiattarella
Francisco Altamirano
Soo Young Kim
Dan Tong
Anwarul Ferdous
Hande Piristine
Subhajit Dasgupta
Xuliang Wang
Kristin M. French
Elisa Villalobos
Stephen B. Spurgin
Maayan Waldman
Nan Jiang
Herman I. May
Theodore M. Hill
Yuxuan Luo
Heesoo Yoo
Vlad G. Zaha
Sergio Lavandero
Thomas G. Gillette
Joseph A. Hill
author_facet Gabriele G. Schiattarella
Francisco Altamirano
Soo Young Kim
Dan Tong
Anwarul Ferdous
Hande Piristine
Subhajit Dasgupta
Xuliang Wang
Kristin M. French
Elisa Villalobos
Stephen B. Spurgin
Maayan Waldman
Nan Jiang
Herman I. May
Theodore M. Hill
Yuxuan Luo
Heesoo Yoo
Vlad G. Zaha
Sergio Lavandero
Thomas G. Gillette
Joseph A. Hill
author_sort Gabriele G. Schiattarella
title Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
title_short Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
title_full Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
title_fullStr Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
title_full_unstemmed Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
title_sort xbp1s-foxo1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5e96ad72a7fc4e428e30cd13deb2825b
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