Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

Background: This study aimed to evaluate the prevalence of restless legs syndrome (RLS) in patients with migraine and explore its association with vitamin D deficiency, aiming to provide biological support for the comorbidity of migraine with RLS, and shed new lights into clinical diagnosis and trea...

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Autores principales:	Shuning Sun, Chunling Liu, Yanlu Jia, Jun Wu, Hui Li, Xiaonan Li, Yimin Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	migraine restless legs syndrome prevalence vitamin D case-control study Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5e995014bd50488f9938c144af358c68
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spelling	oai:doaj.org-article:5e995014bd50488f9938c144af358c682021-11-15T06:47:51ZAssociation Between Migraine Complicated With Restless Legs Syndrome and Vitamin D1664-229510.3389/fneur.2021.777721https://doaj.org/article/5e995014bd50488f9938c144af358c682021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.777721/fullhttps://doaj.org/toc/1664-2295Background: This study aimed to evaluate the prevalence of restless legs syndrome (RLS) in patients with migraine and explore its association with vitamin D deficiency, aiming to provide biological support for the comorbidity of migraine with RLS, and shed new lights into clinical diagnosis and treatment.Methods: A case-control study was performed on 175 migraine patients and 151 non-headache controls. The information of all subjects concerning headache severity [visual analog scale (VAS) score], RLS, RLS severity [International Restless Legs Scale (IRLS) score], sleep quality [Pittsburgh sleep quality index (PSQI)], anxiety and depression symptoms [hospital anxiety and depression scale (HADS)], and demographic data were collected. At the same time, serum 25-(OH) D levels were also measured (concentration <20 ng/ml was defined deficiency). Afterward, the logistic regression model was adopted to explore the risk factors for RLS in patients with migraines.Results: Compared with control group, migraine group had lower vitamin D levels [(21.10 ± 6.58) vs. (16.42 ± 5.6) ng/ml, P < 0.001], a higher rate of vitamin D deficiency (45.03 vs. 72%, P <0001), higher prevalence of RLS (6.62 vs. 22.29%, P < 0.001). Compared with the pure RLS group, RLS with the migraine group had lower vitamin D levels and higher IRLS score (P < 0.05). Compared with pure migraine group, migraine with RLS group had lower vitamin D levels [(17.36 ± 5.56) vs. (13.15 ± 4.42) ng/ml, P < 0.001], higher incidence of vitamin D deficiency (66.18 vs. 92.31%, P = 0.001), higher frequency of headache attacks (P = 0.004). Thereafter, the multivariate logistic regression model was employed to adjust confounding factors such as age, gender, season, frequency of headache attacks, PSQI score, and HADS scores. According to the results vitamin D deficiency in patients with migraines was an independent risk factor for RLS (OR = 5.03, 95%CI: 1.2–21.16, P = 0.027).Conclusions: The prevalence of RLS in migraine patients was significantly higher than that in the non-headache population. Besides, vitamin D levels decreased, while the incidence of vitamin D deficiency increased in the migraine patients complicated with RLS. Finally, the occurrence of RLS in migraine patients was significantly related to vitamin D deficiency.Shuning SunChunling LiuYanlu JiaJun WuHui LiXiaonan LiYimin ZhaoFrontiers Media S.A.articlemigrainerestless legs syndromeprevalencevitamin Dcase-control studyNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	migraine restless legs syndrome prevalence vitamin D case-control study Neurology. Diseases of the nervous system RC346-429
spellingShingle	migraine restless legs syndrome prevalence vitamin D case-control study Neurology. Diseases of the nervous system RC346-429 Shuning Sun Chunling Liu Yanlu Jia Jun Wu Hui Li Xiaonan Li Yimin Zhao Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
description	Background: This study aimed to evaluate the prevalence of restless legs syndrome (RLS) in patients with migraine and explore its association with vitamin D deficiency, aiming to provide biological support for the comorbidity of migraine with RLS, and shed new lights into clinical diagnosis and treatment.Methods: A case-control study was performed on 175 migraine patients and 151 non-headache controls. The information of all subjects concerning headache severity [visual analog scale (VAS) score], RLS, RLS severity [International Restless Legs Scale (IRLS) score], sleep quality [Pittsburgh sleep quality index (PSQI)], anxiety and depression symptoms [hospital anxiety and depression scale (HADS)], and demographic data were collected. At the same time, serum 25-(OH) D levels were also measured (concentration <20 ng/ml was defined deficiency). Afterward, the logistic regression model was adopted to explore the risk factors for RLS in patients with migraines.Results: Compared with control group, migraine group had lower vitamin D levels [(21.10 ± 6.58) vs. (16.42 ± 5.6) ng/ml, P < 0.001], a higher rate of vitamin D deficiency (45.03 vs. 72%, P <0001), higher prevalence of RLS (6.62 vs. 22.29%, P < 0.001). Compared with the pure RLS group, RLS with the migraine group had lower vitamin D levels and higher IRLS score (P < 0.05). Compared with pure migraine group, migraine with RLS group had lower vitamin D levels [(17.36 ± 5.56) vs. (13.15 ± 4.42) ng/ml, P < 0.001], higher incidence of vitamin D deficiency (66.18 vs. 92.31%, P = 0.001), higher frequency of headache attacks (P = 0.004). Thereafter, the multivariate logistic regression model was employed to adjust confounding factors such as age, gender, season, frequency of headache attacks, PSQI score, and HADS scores. According to the results vitamin D deficiency in patients with migraines was an independent risk factor for RLS (OR = 5.03, 95%CI: 1.2–21.16, P = 0.027).Conclusions: The prevalence of RLS in migraine patients was significantly higher than that in the non-headache population. Besides, vitamin D levels decreased, while the incidence of vitamin D deficiency increased in the migraine patients complicated with RLS. Finally, the occurrence of RLS in migraine patients was significantly related to vitamin D deficiency.
format	article
author	Shuning Sun Chunling Liu Yanlu Jia Jun Wu Hui Li Xiaonan Li Yimin Zhao
author_facet	Shuning Sun Chunling Liu Yanlu Jia Jun Wu Hui Li Xiaonan Li Yimin Zhao
author_sort	Shuning Sun
title	Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
title_short	Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
title_full	Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
title_fullStr	Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
title_full_unstemmed	Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D
title_sort	association between migraine complicated with restless legs syndrome and vitamin d
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5e995014bd50488f9938c144af358c68
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Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D

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