A diploid assembly-based benchmark for variants in the major histocompatibility complex
Accurate, phased assemblies are a key tool in understanding the human genome, particularly in highly polymorphic regions like the medically important MHC. Here the authors provide an assembly-based benchmark for this difficult-to-characterize region.
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Nature Portfolio
2020
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oai:doaj.org-article:5e9e6d5734354b4a86ef752be8c0d26e2021-12-02T17:26:56ZA diploid assembly-based benchmark for variants in the major histocompatibility complex10.1038/s41467-020-18564-92041-1723https://doaj.org/article/5e9e6d5734354b4a86ef752be8c0d26e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18564-9https://doaj.org/toc/2041-1723Accurate, phased assemblies are a key tool in understanding the human genome, particularly in highly polymorphic regions like the medically important MHC. Here the authors provide an assembly-based benchmark for this difficult-to-characterize region.Chen-Shan ChinJustin WagnerQiandong ZengErik GarrisonShilpa GargArkarachai FungtammasanMikko RautiainenSergey AganezovMelanie KirscheSamantha ZarateMichael C. SchatzChunlin XiaoWilliam J. RowellCharles MarkelloJesse FarekFritz J. SedlazeckVikas BansalByunggil YooNeil MillerXin ZhouAndrew CarrollAlvaro Martinez BarrioMarc SalitTobias MarschallAlexander T. DiltheyJustin M. ZookNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chen-Shan Chin Justin Wagner Qiandong Zeng Erik Garrison Shilpa Garg Arkarachai Fungtammasan Mikko Rautiainen Sergey Aganezov Melanie Kirsche Samantha Zarate Michael C. Schatz Chunlin Xiao William J. Rowell Charles Markello Jesse Farek Fritz J. Sedlazeck Vikas Bansal Byunggil Yoo Neil Miller Xin Zhou Andrew Carroll Alvaro Martinez Barrio Marc Salit Tobias Marschall Alexander T. Dilthey Justin M. Zook A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| description |
Accurate, phased assemblies are a key tool in understanding the human genome, particularly in highly polymorphic regions like the medically important MHC. Here the authors provide an assembly-based benchmark for this difficult-to-characterize region. |
| format |
article |
| author |
Chen-Shan Chin Justin Wagner Qiandong Zeng Erik Garrison Shilpa Garg Arkarachai Fungtammasan Mikko Rautiainen Sergey Aganezov Melanie Kirsche Samantha Zarate Michael C. Schatz Chunlin Xiao William J. Rowell Charles Markello Jesse Farek Fritz J. Sedlazeck Vikas Bansal Byunggil Yoo Neil Miller Xin Zhou Andrew Carroll Alvaro Martinez Barrio Marc Salit Tobias Marschall Alexander T. Dilthey Justin M. Zook |
| author_facet |
Chen-Shan Chin Justin Wagner Qiandong Zeng Erik Garrison Shilpa Garg Arkarachai Fungtammasan Mikko Rautiainen Sergey Aganezov Melanie Kirsche Samantha Zarate Michael C. Schatz Chunlin Xiao William J. Rowell Charles Markello Jesse Farek Fritz J. Sedlazeck Vikas Bansal Byunggil Yoo Neil Miller Xin Zhou Andrew Carroll Alvaro Martinez Barrio Marc Salit Tobias Marschall Alexander T. Dilthey Justin M. Zook |
| author_sort |
Chen-Shan Chin |
| title |
A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| title_short |
A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| title_full |
A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| title_fullStr |
A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| title_full_unstemmed |
A diploid assembly-based benchmark for variants in the major histocompatibility complex |
| title_sort |
diploid assembly-based benchmark for variants in the major histocompatibility complex |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/5e9e6d5734354b4a86ef752be8c0d26e |
| work_keys_str_mv |
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