Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients

Abstract We explored the association between diabetes mellitus (DM) and the risk of hepatitis C virus (HCV)-related liver cirrhosis in Chinese patients with chronic hepatitis C (CHC). To examine the link between DM and liver cirrhosis, we conducted a case-control study of 210 Chinese CHC patients di...

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Autores principales:	Xu Li, Yang Gao, Hongqin Xu, Jie Hou, Pujun Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5e9f848bf2814eb7b2de6e3d36c5fc2d
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spelling	oai:doaj.org-article:5e9f848bf2814eb7b2de6e3d36c5fc2d2021-12-02T11:51:11ZDiabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients10.1038/s41598-017-09825-72045-2322https://doaj.org/article/5e9f848bf2814eb7b2de6e3d36c5fc2d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09825-7https://doaj.org/toc/2045-2322Abstract We explored the association between diabetes mellitus (DM) and the risk of hepatitis C virus (HCV)-related liver cirrhosis in Chinese patients with chronic hepatitis C (CHC). To examine the link between DM and liver cirrhosis, we conducted a case-control study of 210 Chinese CHC patients diagnosed with liver cirrhosis, comparing them to an age- and sex-matched control group of 431 CHC patients without liver cirrhosis. We conducted logistic regression analyses adjusting for demographic features and liver cirrhosis risk factors, and found that DM increased the risk of developing liver cirrhosis 2-fold [adjusted odds ratio (AOR), 2.132; 95% confidence interval (CI), 1.344–3.382]. Furthermore, the proportion of liver cirrhosis patients and CHC-only patients with elevated serum triglycerides (>1.8 mmol/L) were 5.2% and 17.4%, respectively, yielding an AOR of 0.264 (95% CI, 0.135–0.517). Multivariate analyses that stratified the risk of developing HCV-related liver cirrhosis in DM patients by gender revealed that the estimated AOR (95% CI) for males was 0.415 (0.178–0.969). In conclusion, DM was associated with an increased risk of developing liver cirrhosis in CHC patients in China. Furthermore, among patients diagnosed with both CHC and DM, females had an increased risk of liver cirrhosis development.Xu LiYang GaoHongqin XuJie HouPujun GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xu Li Yang Gao Hongqin Xu Jie Hou Pujun Gao Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
description	Abstract We explored the association between diabetes mellitus (DM) and the risk of hepatitis C virus (HCV)-related liver cirrhosis in Chinese patients with chronic hepatitis C (CHC). To examine the link between DM and liver cirrhosis, we conducted a case-control study of 210 Chinese CHC patients diagnosed with liver cirrhosis, comparing them to an age- and sex-matched control group of 431 CHC patients without liver cirrhosis. We conducted logistic regression analyses adjusting for demographic features and liver cirrhosis risk factors, and found that DM increased the risk of developing liver cirrhosis 2-fold [adjusted odds ratio (AOR), 2.132; 95% confidence interval (CI), 1.344–3.382]. Furthermore, the proportion of liver cirrhosis patients and CHC-only patients with elevated serum triglycerides (>1.8 mmol/L) were 5.2% and 17.4%, respectively, yielding an AOR of 0.264 (95% CI, 0.135–0.517). Multivariate analyses that stratified the risk of developing HCV-related liver cirrhosis in DM patients by gender revealed that the estimated AOR (95% CI) for males was 0.415 (0.178–0.969). In conclusion, DM was associated with an increased risk of developing liver cirrhosis in CHC patients in China. Furthermore, among patients diagnosed with both CHC and DM, females had an increased risk of liver cirrhosis development.
format	article
author	Xu Li Yang Gao Hongqin Xu Jie Hou Pujun Gao
author_facet	Xu Li Yang Gao Hongqin Xu Jie Hou Pujun Gao
author_sort	Xu Li
title	Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
title_short	Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
title_full	Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
title_fullStr	Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
title_full_unstemmed	Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients
title_sort	diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis c patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5e9f848bf2814eb7b2de6e3d36c5fc2d
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Diabetes mellitus is a significant risk factor for the development of liver cirrhosis in chronic hepatitis C patients

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