Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing paracrine Wnt/β-catenin signaling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucy Brunt, Gediminas Greicius, Sally Rogers, Benjamin D. Evans, David M. Virshup, Kyle C. A. Wedgwood, Steffen Scholpp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ea0c3f9e6304004a8bd71cac78f963e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5ea0c3f9e6304004a8bd71cac78f963e
record_format	dspace
spelling	oai:doaj.org-article:5ea0c3f9e6304004a8bd71cac78f963e2021-12-02T14:37:37ZVangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling10.1038/s41467-021-22393-92041-1723https://doaj.org/article/5ea0c3f9e6304004a8bd71cac78f963e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22393-9https://doaj.org/toc/2041-1723Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing paracrine Wnt/β-catenin signaling.Lucy BruntGediminas GreiciusSally RogersBenjamin D. EvansDavid M. VirshupKyle C. A. WedgwoodSteffen ScholppNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucy Brunt Gediminas Greicius Sally Rogers Benjamin D. Evans David M. Virshup Kyle C. A. Wedgwood Steffen Scholpp Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
description	Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing paracrine Wnt/β-catenin signaling.
format	article
author	Lucy Brunt Gediminas Greicius Sally Rogers Benjamin D. Evans David M. Virshup Kyle C. A. Wedgwood Steffen Scholpp
author_facet	Lucy Brunt Gediminas Greicius Sally Rogers Benjamin D. Evans David M. Virshup Kyle C. A. Wedgwood Steffen Scholpp
author_sort	Lucy Brunt
title	Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
title_short	Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
title_full	Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
title_fullStr	Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
title_full_unstemmed	Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling
title_sort	vangl2 promotes the formation of long cytonemes to enable distant wnt/β-catenin signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ea0c3f9e6304004a8bd71cac78f963e
work_keys_str_mv	AT lucybrunt vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT gediminasgreicius vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT sallyrogers vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT benjamindevans vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT davidmvirshup vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT kylecawedgwood vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling AT steffenscholpp vangl2promotestheformationoflongcytonemestoenabledistantwntbcateninsignaling
_version_	1718391007998902272

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Ejemplares similares