Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic seed and target system in Drosophila which ma...

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Autores principales:	Ramona F. Sowade, Thomas R. Jahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ea36811b67d402494721fe6e7ac972b
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spelling	oai:doaj.org-article:5ea36811b67d402494721fe6e7ac972b2021-12-02T14:42:24ZSeed-induced acceleration of amyloid-β mediated neurotoxicity in vivo10.1038/s41467-017-00579-42041-1723https://doaj.org/article/5ea36811b67d402494721fe6e7ac972b2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00579-4https://doaj.org/toc/2041-1723Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic seed and target system in Drosophila which may be useful for the mechanistic study of seeding of amyloid in vivo.Ramona F. SowadeThomas R. JahnNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramona F. Sowade Thomas R. Jahn Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
description	Seeding of amyloid beta from one brain region to another is thought to contribute to the progression of Alzheimer’s disease, although to date most studies have depended on inoculation of animals with exogenous amyloid. Here the authors describe a genetic seed and target system in Drosophila which may be useful for the mechanistic study of seeding of amyloid in vivo.
format	article
author	Ramona F. Sowade Thomas R. Jahn
author_facet	Ramona F. Sowade Thomas R. Jahn
author_sort	Ramona F. Sowade
title	Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
title_short	Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
title_full	Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
title_fullStr	Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
title_full_unstemmed	Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
title_sort	seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5ea36811b67d402494721fe6e7ac972b
work_keys_str_mv	AT ramonafsowade seedinducedaccelerationofamyloidbmediatedneurotoxicityinvivo AT thomasrjahn seedinducedaccelerationofamyloidbmediatedneurotoxicityinvivo
_version_	1718389691222327296

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

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