MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Reactive oxygen species (ROS) damage cell components, necessitating their clearance through autophagy. Here, the authors show that ROS can induce autophagy by triggering TRPML1 to release Ca2+from the lysosomal lumen, in turn activating the autophagy and lysosomal biogenesis regulator TFEB.

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Autores principales:	Xiaoli Zhang, Xiping Cheng, Lu Yu, Junsheng Yang, Raul Calvo, Samarjit Patnaik, Xin Hu, Qiong Gao, Meimei Yang, Maria Lawas, Markus Delling, Juan Marugan, Marc Ferrer, Haoxing Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ea7884007644b998455beef98724838
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spelling	oai:doaj.org-article:5ea7884007644b998455beef987248382021-12-02T17:32:04ZMCOLN1 is a ROS sensor in lysosomes that regulates autophagy10.1038/ncomms121092041-1723https://doaj.org/article/5ea7884007644b998455beef987248382016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12109https://doaj.org/toc/2041-1723Reactive oxygen species (ROS) damage cell components, necessitating their clearance through autophagy. Here, the authors show that ROS can induce autophagy by triggering TRPML1 to release Ca2+from the lysosomal lumen, in turn activating the autophagy and lysosomal biogenesis regulator TFEB.Xiaoli ZhangXiping ChengLu YuJunsheng YangRaul CalvoSamarjit PatnaikXin HuQiong GaoMeimei YangMaria LawasMarkus DellingJuan MaruganMarc FerrerHaoxing XuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoli Zhang Xiping Cheng Lu Yu Junsheng Yang Raul Calvo Samarjit Patnaik Xin Hu Qiong Gao Meimei Yang Maria Lawas Markus Delling Juan Marugan Marc Ferrer Haoxing Xu MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
description	Reactive oxygen species (ROS) damage cell components, necessitating their clearance through autophagy. Here, the authors show that ROS can induce autophagy by triggering TRPML1 to release Ca2+from the lysosomal lumen, in turn activating the autophagy and lysosomal biogenesis regulator TFEB.
format	article
author	Xiaoli Zhang Xiping Cheng Lu Yu Junsheng Yang Raul Calvo Samarjit Patnaik Xin Hu Qiong Gao Meimei Yang Maria Lawas Markus Delling Juan Marugan Marc Ferrer Haoxing Xu
author_facet	Xiaoli Zhang Xiping Cheng Lu Yu Junsheng Yang Raul Calvo Samarjit Patnaik Xin Hu Qiong Gao Meimei Yang Maria Lawas Markus Delling Juan Marugan Marc Ferrer Haoxing Xu
author_sort	Xiaoli Zhang
title	MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
title_short	MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
title_full	MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
title_fullStr	MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
title_full_unstemmed	MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
title_sort	mcoln1 is a ros sensor in lysosomes that regulates autophagy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5ea7884007644b998455beef98724838
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MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

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