Translational Control in Liver Disease
Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic facto...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:5ea7de9d3b4c491f9447c5038a68ee802021-12-01T13:50:09ZTranslational Control in Liver Disease1664-042X10.3389/fphys.2021.795298https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.795298/fullhttps://doaj.org/toc/1664-042XChronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.Alexandra BalveyMercedes FernandezFrontiers Media S.A.articletranslationRNA-binding proteinsCPEB proteinsliver diseaseportal hypertensionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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translation RNA-binding proteins CPEB proteins liver disease portal hypertension Physiology QP1-981 |
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translation RNA-binding proteins CPEB proteins liver disease portal hypertension Physiology QP1-981 Alexandra Balvey Mercedes Fernandez Translational Control in Liver Disease |
description |
Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development. |
format |
article |
author |
Alexandra Balvey Mercedes Fernandez |
author_facet |
Alexandra Balvey Mercedes Fernandez |
author_sort |
Alexandra Balvey |
title |
Translational Control in Liver Disease |
title_short |
Translational Control in Liver Disease |
title_full |
Translational Control in Liver Disease |
title_fullStr |
Translational Control in Liver Disease |
title_full_unstemmed |
Translational Control in Liver Disease |
title_sort |
translational control in liver disease |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee80 |
work_keys_str_mv |
AT alexandrabalvey translationalcontrolinliverdisease AT mercedesfernandez translationalcontrolinliverdisease |
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1718405060672618496 |