Translational Control in Liver Disease

Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic facto...

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Autores principales: Alexandra Balvey, Mercedes Fernandez
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee80
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spelling oai:doaj.org-article:5ea7de9d3b4c491f9447c5038a68ee802021-12-01T13:50:09ZTranslational Control in Liver Disease1664-042X10.3389/fphys.2021.795298https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.795298/fullhttps://doaj.org/toc/1664-042XChronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.Alexandra BalveyMercedes FernandezFrontiers Media S.A.articletranslationRNA-binding proteinsCPEB proteinsliver diseaseportal hypertensionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic translation
RNA-binding proteins
CPEB proteins
liver disease
portal hypertension
Physiology
QP1-981
spellingShingle translation
RNA-binding proteins
CPEB proteins
liver disease
portal hypertension
Physiology
QP1-981
Alexandra Balvey
Mercedes Fernandez
Translational Control in Liver Disease
description Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.
format article
author Alexandra Balvey
Mercedes Fernandez
author_facet Alexandra Balvey
Mercedes Fernandez
author_sort Alexandra Balvey
title Translational Control in Liver Disease
title_short Translational Control in Liver Disease
title_full Translational Control in Liver Disease
title_fullStr Translational Control in Liver Disease
title_full_unstemmed Translational Control in Liver Disease
title_sort translational control in liver disease
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee80
work_keys_str_mv AT alexandrabalvey translationalcontrolinliverdisease
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