Translational Control in Liver Disease

Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic facto...

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Autores principales:	Alexandra Balvey, Mercedes Fernandez
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	translation RNA-binding proteins CPEB proteins liver disease portal hypertension Physiology QP1-981
Acceso en línea:	https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee80
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id	oai:doaj.org-article:5ea7de9d3b4c491f9447c5038a68ee80
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spelling	oai:doaj.org-article:5ea7de9d3b4c491f9447c5038a68ee802021-12-01T13:50:09ZTranslational Control in Liver Disease1664-042X10.3389/fphys.2021.795298https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.795298/fullhttps://doaj.org/toc/1664-042XChronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.Alexandra BalveyMercedes FernandezFrontiers Media S.A.articletranslationRNA-binding proteinsCPEB proteinsliver diseaseportal hypertensionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	translation RNA-binding proteins CPEB proteins liver disease portal hypertension Physiology QP1-981
spellingShingle	translation RNA-binding proteins CPEB proteins liver disease portal hypertension Physiology QP1-981 Alexandra Balvey Mercedes Fernandez Translational Control in Liver Disease
description	Chronic liver disease is one of the biggest threats to public health worldwide. Worryingly, the incidence of liver disease is dramatically rising due to the aging of the population and the global epidemics of obesity. Both are major risk factors for chronic liver disease and adverse prognostic factors, causing an increase in mortality rate. It is of great concern that 80–95% of obese people have non-alcoholic fatty liver disease, the major precursor for liver failure and a global health challenge. Currently, the only curative treatment for advanced chronic liver disease is liver transplantation, which is, however, hampered by high treatment costs and the scarcity of donor organs. New strategies are therefore urgently needed to prevent and reverse chronic liver disease. And for that it is essential to understand better the molecular mechanisms underlying human disease. This review focuses on the abnormalities in the regulation of translation by RNA-binding proteins during chronic liver disease and their pathological impact on portal hypertension, fibrosis, steatosis, neovascularization, and cancer development.
format	article
author	Alexandra Balvey Mercedes Fernandez
author_facet	Alexandra Balvey Mercedes Fernandez
author_sort	Alexandra Balvey
title	Translational Control in Liver Disease
title_short	Translational Control in Liver Disease
title_full	Translational Control in Liver Disease
title_fullStr	Translational Control in Liver Disease
title_full_unstemmed	Translational Control in Liver Disease
title_sort	translational control in liver disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5ea7de9d3b4c491f9447c5038a68ee80
work_keys_str_mv	AT alexandrabalvey translationalcontrolinliverdisease AT mercedesfernandez translationalcontrolinliverdisease
_version_	1718405060672618496

Translational Control in Liver Disease

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