A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking and NPC1-dependent lysosomal cholesterol export.

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Autores principales:	Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ea86788f5ff452193f198cb9ba6bdd4
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spelling	oai:doaj.org-article:5ea86788f5ff452193f198cb9ba6bdd42021-12-02T15:39:24ZA trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export10.1038/s41467-020-19032-02041-1723https://doaj.org/article/5ea86788f5ff452193f198cb9ba6bdd42020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19032-0https://doaj.org/toc/2041-1723Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking and NPC1-dependent lysosomal cholesterol export.Dick J. H. van den BoomenAgata SienkiewiczIlana BerlinMarlieke L. M. JongsmaDaphne M. van ElslandJ. Paul LuzioJacques J. C. NeefjesPaul J. LehnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dick J. H. van den Boomen Agata Sienkiewicz Ilana Berlin Marlieke L. M. Jongsma Daphne M. van Elsland J. Paul Luzio Jacques J. C. Neefjes Paul J. Lehner A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
description	Lysosomes play an important role in cellular LDL-cholesterol uptake. Here, the authors perform a genome-wide genetic screen for cholesterol regulators and identify C18orf8 as a conserved subunit of a trimeric Rab7 GEF that controls LDL trafficking and NPC1-dependent lysosomal cholesterol export.
format	article
author	Dick J. H. van den Boomen Agata Sienkiewicz Ilana Berlin Marlieke L. M. Jongsma Daphne M. van Elsland J. Paul Luzio Jacques J. C. Neefjes Paul J. Lehner
author_facet	Dick J. H. van den Boomen Agata Sienkiewicz Ilana Berlin Marlieke L. M. Jongsma Daphne M. van Elsland J. Paul Luzio Jacques J. C. Neefjes Paul J. Lehner
author_sort	Dick J. H. van den Boomen
title	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
title_short	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
title_full	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
title_fullStr	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
title_full_unstemmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
title_sort	trimeric rab7 gef controls npc1-dependent lysosomal cholesterol export
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5ea86788f5ff452193f198cb9ba6bdd4
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A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

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