Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements

Background: Resting state beta band (13–30 Hz) oscillations represent pathological neural activity in Parkinson’s disease (PD). It is unknown how the peak frequency or dynamics of beta oscillations may change among fine, limb, and axial movements and different disease phenotypes. This will be critic...

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Autores principales:	Raumin S. Neuville, Matthew N. Petrucci, Kevin B. Wilkins, Ross W. Anderson, Shannon L. Hoffman, Jordan E. Parker, Anca Velisar, Helen M. Bronte-Stewart
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	beta oscillations Parkinson’s disease (PD) local field potentials (LFP) subthalamic nucleus (STN) deep brain stimulation (DBS) beta bursts Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5eb1c0558a3347969c7fabf1e6024055
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spelling	oai:doaj.org-article:5eb1c0558a3347969c7fabf1e60240552021-11-11T06:06:02ZDifferential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements1662-453X10.3389/fnins.2021.733203https://doaj.org/article/5eb1c0558a3347969c7fabf1e60240552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.733203/fullhttps://doaj.org/toc/1662-453XBackground: Resting state beta band (13–30 Hz) oscillations represent pathological neural activity in Parkinson’s disease (PD). It is unknown how the peak frequency or dynamics of beta oscillations may change among fine, limb, and axial movements and different disease phenotypes. This will be critical for the development of personalized closed loop deep brain stimulation (DBS) algorithms during different activity states.Methods: Subthalamic (STN) and local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC + S, Medtronic PLC.) in fourteen PD participants (six tremor-dominant and eight akinetic-rigid) off medication/off STN DBS during 30 s of repetitive alternating finger tapping, wrist-flexion extension, stepping in place, and free walking. Beta power peaks and beta burst dynamics were identified by custom algorithms and were compared among movement tasks and between tremor-dominant and akinetic-rigid groups.Results: Beta power peaks were evident during fine, limb, and axial movements in 98% of movement trials; the peak frequencies were similar during each type of movement. Burst power and duration were significantly larger in the high beta band, but not in the low beta band, in the akinetic-rigid group compared to the tremor-dominant group.Conclusion: The conservation of beta peak frequency during different activity states supports the feasibility of patient-specific closed loop DBS algorithms driven by the dynamics of the same beta band during different activities. Akinetic-rigid participants had greater power and longer burst durations in the high beta band than tremor-dominant participants during movement, which may relate to the difference in underlying pathophysiology between phenotypes.Raumin S. NeuvilleRaumin S. NeuvilleMatthew N. PetrucciKevin B. WilkinsRoss W. AndersonShannon L. HoffmanJordan E. ParkerJordan E. ParkerAnca VelisarAnca VelisarHelen M. Bronte-StewartHelen M. Bronte-StewartFrontiers Media S.A.articlebeta oscillationsParkinson’s disease (PD)local field potentials (LFP)subthalamic nucleus (STN)deep brain stimulation (DBS)beta burstsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beta oscillations Parkinson’s disease (PD) local field potentials (LFP) subthalamic nucleus (STN) deep brain stimulation (DBS) beta bursts Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	beta oscillations Parkinson’s disease (PD) local field potentials (LFP) subthalamic nucleus (STN) deep brain stimulation (DBS) beta bursts Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Raumin S. Neuville Raumin S. Neuville Matthew N. Petrucci Kevin B. Wilkins Ross W. Anderson Shannon L. Hoffman Jordan E. Parker Jordan E. Parker Anca Velisar Anca Velisar Helen M. Bronte-Stewart Helen M. Bronte-Stewart Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
description	Background: Resting state beta band (13–30 Hz) oscillations represent pathological neural activity in Parkinson’s disease (PD). It is unknown how the peak frequency or dynamics of beta oscillations may change among fine, limb, and axial movements and different disease phenotypes. This will be critical for the development of personalized closed loop deep brain stimulation (DBS) algorithms during different activity states.Methods: Subthalamic (STN) and local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC + S, Medtronic PLC.) in fourteen PD participants (six tremor-dominant and eight akinetic-rigid) off medication/off STN DBS during 30 s of repetitive alternating finger tapping, wrist-flexion extension, stepping in place, and free walking. Beta power peaks and beta burst dynamics were identified by custom algorithms and were compared among movement tasks and between tremor-dominant and akinetic-rigid groups.Results: Beta power peaks were evident during fine, limb, and axial movements in 98% of movement trials; the peak frequencies were similar during each type of movement. Burst power and duration were significantly larger in the high beta band, but not in the low beta band, in the akinetic-rigid group compared to the tremor-dominant group.Conclusion: The conservation of beta peak frequency during different activity states supports the feasibility of patient-specific closed loop DBS algorithms driven by the dynamics of the same beta band during different activities. Akinetic-rigid participants had greater power and longer burst durations in the high beta band than tremor-dominant participants during movement, which may relate to the difference in underlying pathophysiology between phenotypes.
format	article
author	Raumin S. Neuville Raumin S. Neuville Matthew N. Petrucci Kevin B. Wilkins Ross W. Anderson Shannon L. Hoffman Jordan E. Parker Jordan E. Parker Anca Velisar Anca Velisar Helen M. Bronte-Stewart Helen M. Bronte-Stewart
author_facet	Raumin S. Neuville Raumin S. Neuville Matthew N. Petrucci Kevin B. Wilkins Ross W. Anderson Shannon L. Hoffman Jordan E. Parker Jordan E. Parker Anca Velisar Anca Velisar Helen M. Bronte-Stewart Helen M. Bronte-Stewart
author_sort	Raumin S. Neuville
title	Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
title_short	Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
title_full	Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
title_fullStr	Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
title_full_unstemmed	Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements
title_sort	differential effects of pathological beta burst dynamics between parkinson’s disease phenotypes across different movements
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5eb1c0558a3347969c7fabf1e6024055
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Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements

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