Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study

Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study

Abstract Sepsis is the most common cause of in-hospital deaths, especially from low-income and lower-middle-income countries (LMICs). This study aimed to investigate the mortality rate and associated factors from sepsis in intensive care units (ICUs) in an LMIC. We did a multicenter cross-sectional...

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Autores principales: Son Ngoc Do, Chinh Quoc Luong, Dung Thi Pham, My Ha Nguyen, Nga Thi Nguyen, Dai Quang Huynh, Quoc Trong Ai Hoang, Co Xuan Dao, Trung Minh Le, Ha Nhat Bui, Hung Tan Nguyen, Hai Bui Hoang, Thuy Thi Phuong Le, Lien Thi Bao Nguyen, Phuoc Thien Duong, Tuan Dang Nguyen, Yen Hai Vu, Giang Thi Tra Pham, Tam Van Bui, Thao Thi Ngoc Pham, Hanh Trong Hoang, Cuong Van Bui, Nguyen Minh Nguyen, Giang Thi Huong Bui, Thang Dinh Vu, Nhan Duc Le, Trang Huyen Tran, Thang Quang Nguyen, Vuong Hung Le, Chi Van Nguyen, Bryan Francis McNally, Jason Phua, Anh Dat Nguyen
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:5eb45003c96d4aa58532fd39ff1754902021-12-02T18:48:23ZFactors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study10.1038/s41598-021-98165-82045-2322https://doaj.org/article/5eb45003c96d4aa58532fd39ff1754902021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98165-8https://doaj.org/toc/2045-2322Abstract Sepsis is the most common cause of in-hospital deaths, especially from low-income and lower-middle-income countries (LMICs). This study aimed to investigate the mortality rate and associated factors from sepsis in intensive care units (ICUs) in an LMIC. We did a multicenter cross-sectional study of septic patients presenting to 15 adult ICUs throughout Vietnam on the 4 days representing the different seasons of 2019. Of 252 patients, 40.1% died in hospital and 33.3% died in ICU. ICUs with accredited training programs (odds ratio, OR: 0.309; 95% confidence interval, CI 0.122–0.783) and completion of the 3-h sepsis bundle (OR: 0.294; 95% CI 0.083–1.048) were associated with decreased hospital mortality. ICUs with intensivist-to-patient ratio of 1:6 to 8 (OR: 4.533; 95% CI 1.621–12.677), mechanical ventilation (OR: 3.890; 95% CI 1.445–10.474) and renal replacement therapy (OR: 2.816; 95% CI 1.318–6.016) were associated with increased ICU mortality, in contrast to non-surgical source control (OR: 0.292; 95% CI 0.126–0.678) which was associated with decreased ICU mortality. Improvements are needed in the management of sepsis in Vietnam such as increasing resources in critical care settings, making accredited training programs more available, improving compliance with sepsis bundles of care, and treating underlying illness and shock optimally in septic patients.Son Ngoc DoChinh Quoc LuongDung Thi PhamMy Ha NguyenNga Thi NguyenDai Quang HuynhQuoc Trong Ai HoangCo Xuan DaoTrung Minh LeHa Nhat BuiHung Tan NguyenHai Bui HoangThuy Thi Phuong LeLien Thi Bao NguyenPhuoc Thien DuongTuan Dang NguyenYen Hai VuGiang Thi Tra PhamTam Van BuiThao Thi Ngoc PhamHanh Trong HoangCuong Van BuiNguyen Minh NguyenGiang Thi Huong BuiThang Dinh VuNhan Duc LeTrang Huyen TranThang Quang NguyenVuong Hung LeChi Van NguyenBryan Francis McNallyJason PhuaAnh Dat NguyenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Son Ngoc Do
Chinh Quoc Luong
Dung Thi Pham
My Ha Nguyen
Nga Thi Nguyen
Dai Quang Huynh
Quoc Trong Ai Hoang
Co Xuan Dao
Trung Minh Le
Ha Nhat Bui
Hung Tan Nguyen
Hai Bui Hoang
Thuy Thi Phuong Le
Lien Thi Bao Nguyen
Phuoc Thien Duong
Tuan Dang Nguyen
Yen Hai Vu
Giang Thi Tra Pham
Tam Van Bui
Thao Thi Ngoc Pham
Hanh Trong Hoang
Cuong Van Bui
Nguyen Minh Nguyen
Giang Thi Huong Bui
Thang Dinh Vu
Nhan Duc Le
Trang Huyen Tran
Thang Quang Nguyen
Vuong Hung Le
Chi Van Nguyen
Bryan Francis McNally
Jason Phua
Anh Dat Nguyen
Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
description Abstract Sepsis is the most common cause of in-hospital deaths, especially from low-income and lower-middle-income countries (LMICs). This study aimed to investigate the mortality rate and associated factors from sepsis in intensive care units (ICUs) in an LMIC. We did a multicenter cross-sectional study of septic patients presenting to 15 adult ICUs throughout Vietnam on the 4 days representing the different seasons of 2019. Of 252 patients, 40.1% died in hospital and 33.3% died in ICU. ICUs with accredited training programs (odds ratio, OR: 0.309; 95% confidence interval, CI 0.122–0.783) and completion of the 3-h sepsis bundle (OR: 0.294; 95% CI 0.083–1.048) were associated with decreased hospital mortality. ICUs with intensivist-to-patient ratio of 1:6 to 8 (OR: 4.533; 95% CI 1.621–12.677), mechanical ventilation (OR: 3.890; 95% CI 1.445–10.474) and renal replacement therapy (OR: 2.816; 95% CI 1.318–6.016) were associated with increased ICU mortality, in contrast to non-surgical source control (OR: 0.292; 95% CI 0.126–0.678) which was associated with decreased ICU mortality. Improvements are needed in the management of sepsis in Vietnam such as increasing resources in critical care settings, making accredited training programs more available, improving compliance with sepsis bundles of care, and treating underlying illness and shock optimally in septic patients.
format article
author Son Ngoc Do
Chinh Quoc Luong
Dung Thi Pham
My Ha Nguyen
Nga Thi Nguyen
Dai Quang Huynh
Quoc Trong Ai Hoang
Co Xuan Dao
Trung Minh Le
Ha Nhat Bui
Hung Tan Nguyen
Hai Bui Hoang
Thuy Thi Phuong Le
Lien Thi Bao Nguyen
Phuoc Thien Duong
Tuan Dang Nguyen
Yen Hai Vu
Giang Thi Tra Pham
Tam Van Bui
Thao Thi Ngoc Pham
Hanh Trong Hoang
Cuong Van Bui
Nguyen Minh Nguyen
Giang Thi Huong Bui
Thang Dinh Vu
Nhan Duc Le
Trang Huyen Tran
Thang Quang Nguyen
Vuong Hung Le
Chi Van Nguyen
Bryan Francis McNally
Jason Phua
Anh Dat Nguyen
author_facet Son Ngoc Do
Chinh Quoc Luong
Dung Thi Pham
My Ha Nguyen
Nga Thi Nguyen
Dai Quang Huynh
Quoc Trong Ai Hoang
Co Xuan Dao
Trung Minh Le
Ha Nhat Bui
Hung Tan Nguyen
Hai Bui Hoang
Thuy Thi Phuong Le
Lien Thi Bao Nguyen
Phuoc Thien Duong
Tuan Dang Nguyen
Yen Hai Vu
Giang Thi Tra Pham
Tam Van Bui
Thao Thi Ngoc Pham
Hanh Trong Hoang
Cuong Van Bui
Nguyen Minh Nguyen
Giang Thi Huong Bui
Thang Dinh Vu
Nhan Duc Le
Trang Huyen Tran
Thang Quang Nguyen
Vuong Hung Le
Chi Van Nguyen
Bryan Francis McNally
Jason Phua
Anh Dat Nguyen
author_sort Son Ngoc Do
title Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
title_short Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
title_full Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
title_fullStr Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
title_full_unstemmed Factors relating to mortality in septic patients in Vietnamese intensive care units from a subgroup analysis of MOSAICS II study
title_sort factors relating to mortality in septic patients in vietnamese intensive care units from a subgroup analysis of mosaics ii study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5eb45003c96d4aa58532fd39ff175490
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