Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis

Fecal microbiota transplantation and probiotics have been tested/used as potential therapeutics against inflammatory bowel diseases (IBD). Here the authors use a bottom-up rational consortium design approach that combines well-characterized strains isolated from healthy human stool samples to produc...

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Autores principales:	Daniel van der Lelie, Akihiko Oka, Safiyh Taghavi, Junji Umeno, Ting-Jia Fan, Katherine E. Merrell, Sarah D. Watson, Lisa Ouellette, Bo Liu, Muyiwa Awoniyi, Yunjia Lai, Liang Chi, Kun Lu, Christopher S. Henry, R. Balfour Sartor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5eb6b389fe5147e39c08cf643fd1bdcd
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spelling	oai:doaj.org-article:5eb6b389fe5147e39c08cf643fd1bdcd2021-12-02T16:53:16ZRationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis10.1038/s41467-021-23460-x2041-1723https://doaj.org/article/5eb6b389fe5147e39c08cf643fd1bdcd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23460-xhttps://doaj.org/toc/2041-1723Fecal microbiota transplantation and probiotics have been tested/used as potential therapeutics against inflammatory bowel diseases (IBD). Here the authors use a bottom-up rational consortium design approach that combines well-characterized strains isolated from healthy human stool samples to produce two consortia of metabolically interdependent strains for the treatment of IBD.Daniel van der LelieAkihiko OkaSafiyh TaghaviJunji UmenoTing-Jia FanKatherine E. MerrellSarah D. WatsonLisa OuelletteBo LiuMuyiwa AwoniyiYunjia LaiLiang ChiKun LuChristopher S. HenryR. Balfour SartorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel van der Lelie Akihiko Oka Safiyh Taghavi Junji Umeno Ting-Jia Fan Katherine E. Merrell Sarah D. Watson Lisa Ouellette Bo Liu Muyiwa Awoniyi Yunjia Lai Liang Chi Kun Lu Christopher S. Henry R. Balfour Sartor Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
description	Fecal microbiota transplantation and probiotics have been tested/used as potential therapeutics against inflammatory bowel diseases (IBD). Here the authors use a bottom-up rational consortium design approach that combines well-characterized strains isolated from healthy human stool samples to produce two consortia of metabolically interdependent strains for the treatment of IBD.
format	article
author	Daniel van der Lelie Akihiko Oka Safiyh Taghavi Junji Umeno Ting-Jia Fan Katherine E. Merrell Sarah D. Watson Lisa Ouellette Bo Liu Muyiwa Awoniyi Yunjia Lai Liang Chi Kun Lu Christopher S. Henry R. Balfour Sartor
author_facet	Daniel van der Lelie Akihiko Oka Safiyh Taghavi Junji Umeno Ting-Jia Fan Katherine E. Merrell Sarah D. Watson Lisa Ouellette Bo Liu Muyiwa Awoniyi Yunjia Lai Liang Chi Kun Lu Christopher S. Henry R. Balfour Sartor
author_sort	Daniel van der Lelie
title	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
title_short	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
title_full	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
title_fullStr	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
title_full_unstemmed	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
title_sort	rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5eb6b389fe5147e39c08cf643fd1bdcd
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Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis

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