Growth-coupled selection of synthetic modules to accelerate cell factory development

Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproductio...

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Autores principales:	Enrico Orsi, Nico J. Claassens, Pablo I. Nikel, Steffen N. Lindner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ebc81f6c35544e2ac164e08644dbd86
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spelling	oai:doaj.org-article:5ebc81f6c35544e2ac164e08644dbd862021-12-02T14:55:09ZGrowth-coupled selection of synthetic modules to accelerate cell factory development10.1038/s41467-021-25665-62041-1723https://doaj.org/article/5ebc81f6c35544e2ac164e08644dbd862021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25665-6https://doaj.org/toc/2041-1723Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.Enrico OrsiNico J. ClaassensPablo I. NikelSteffen N. LindnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enrico Orsi Nico J. Claassens Pablo I. Nikel Steffen N. Lindner Growth-coupled selection of synthetic modules to accelerate cell factory development
description	Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.
format	article
author	Enrico Orsi Nico J. Claassens Pablo I. Nikel Steffen N. Lindner
author_facet	Enrico Orsi Nico J. Claassens Pablo I. Nikel Steffen N. Lindner
author_sort	Enrico Orsi
title	Growth-coupled selection of synthetic modules to accelerate cell factory development
title_short	Growth-coupled selection of synthetic modules to accelerate cell factory development
title_full	Growth-coupled selection of synthetic modules to accelerate cell factory development
title_fullStr	Growth-coupled selection of synthetic modules to accelerate cell factory development
title_full_unstemmed	Growth-coupled selection of synthetic modules to accelerate cell factory development
title_sort	growth-coupled selection of synthetic modules to accelerate cell factory development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ebc81f6c35544e2ac164e08644dbd86
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Growth-coupled selection of synthetic modules to accelerate cell factory development

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