The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 at Al-Shif...

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Autores principales:	Zainab Thanon Hasan, Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji, Dr. Ahmed Kayes Mehuaiden
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	COVID-19 Melatonin Clinical trial Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5ebdae9ed75d4966b2a0ba715cf2659a
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spelling	oai:doaj.org-article:5ebdae9ed75d4966b2a0ba715cf2659a2021-11-28T04:29:15ZThe Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients1201-971210.1016/j.ijid.2021.10.012https://doaj.org/article/5ebdae9ed75d4966b2a0ba715cf2659a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007980https://doaj.org/toc/1201-9712Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 at Al-Shifaa hospital in Mosul, Iraq. There were 158 patients with severe COVID-19 included in the study: 82 in the melatonin group (who received 10 mg melatonin in addition to standard therapeutic care) and 76 in the control group (given standard therapeutic care only). Patients were chosen by a blocked randomization design. The physician then evaluated and recorded the incidence of thrombosis, sepsis, and mortality rate on days 5, 11, and 17 of symptoms. Results: The intervention group consisted of 82 patients, while the control group consisted of 76 patients. In comparison to the control group, thrombosis and sepsis developed significantly less frequently (P < 0.05) in the melatonin group during the second week of infection, while mortality was significantly higher in the control group (P < 0.05). Conclusions: Adjuvant use of melatonin may help to reduce thrombosis, sepsis, and mortality in COVID-19 patients.Zainab Thanon HasanDr. Mohammed Qasim Yahya Mal Allah Al AtrakjiDr. Ahmed Kayes MehuaidenElsevierarticleCOVID-19MelatoninClinical trialInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 114, Iss , Pp 79-84 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Melatonin Clinical trial Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 Melatonin Clinical trial Infectious and parasitic diseases RC109-216 Zainab Thanon Hasan Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji Dr. Ahmed Kayes Mehuaiden The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
description	Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 at Al-Shifaa hospital in Mosul, Iraq. There were 158 patients with severe COVID-19 included in the study: 82 in the melatonin group (who received 10 mg melatonin in addition to standard therapeutic care) and 76 in the control group (given standard therapeutic care only). Patients were chosen by a blocked randomization design. The physician then evaluated and recorded the incidence of thrombosis, sepsis, and mortality rate on days 5, 11, and 17 of symptoms. Results: The intervention group consisted of 82 patients, while the control group consisted of 76 patients. In comparison to the control group, thrombosis and sepsis developed significantly less frequently (P < 0.05) in the melatonin group during the second week of infection, while mortality was significantly higher in the control group (P < 0.05). Conclusions: Adjuvant use of melatonin may help to reduce thrombosis, sepsis, and mortality in COVID-19 patients.
format	article
author	Zainab Thanon Hasan Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji Dr. Ahmed Kayes Mehuaiden
author_facet	Zainab Thanon Hasan Dr. Mohammed Qasim Yahya Mal Allah Al Atrakji Dr. Ahmed Kayes Mehuaiden
author_sort	Zainab Thanon Hasan
title	The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
title_short	The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
title_full	The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
title_fullStr	The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
title_full_unstemmed	The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients
title_sort	effect of melatonin on thrombosis, sepsis and mortality rate in covid-19 patients
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/5ebdae9ed75d4966b2a0ba715cf2659a
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The Effect of Melatonin on Thrombosis, Sepsis and Mortality Rate in COVID-19 Patients

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