Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architecture and glycosylation of the native cleaved trimer...

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Autores principales:	Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ebe9459afc54000bd784b1509c2346e
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spelling	oai:doaj.org-article:5ebe9459afc54000bd784b1509c2346e2021-12-02T17:31:57ZStructure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer10.1038/s41467-018-04272-y2041-1723https://doaj.org/article/5ebe9459afc54000bd784b1509c2346e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04272-yhttps://doaj.org/toc/2041-1723Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architecture and glycosylation of the native cleaved trimer.Anita SarkarShridhar BaleAnna-Janina BehrensSonu KumarShailendra Kumar SharmaNatalia de ValJesper PallesenAdriana IrimiaDevan C. DiwanjiRobyn L. StanfieldAndrew B. WardMax CrispinRichard T. WyattIan A. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anita Sarkar Shridhar Bale Anna-Janina Behrens Sonu Kumar Shailendra Kumar Sharma Natalia de Val Jesper Pallesen Adriana Irimia Devan C. Diwanji Robyn L. Stanfield Andrew B. Ward Max Crispin Richard T. Wyatt Ian A. Wilson Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
description	Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al. show that a cleavage-independent Env construct recapitulates the architecture and glycosylation of the native cleaved trimer.
format	article
author	Anita Sarkar Shridhar Bale Anna-Janina Behrens Sonu Kumar Shailendra Kumar Sharma Natalia de Val Jesper Pallesen Adriana Irimia Devan C. Diwanji Robyn L. Stanfield Andrew B. Ward Max Crispin Richard T. Wyatt Ian A. Wilson
author_facet	Anita Sarkar Shridhar Bale Anna-Janina Behrens Sonu Kumar Shailendra Kumar Sharma Natalia de Val Jesper Pallesen Adriana Irimia Devan C. Diwanji Robyn L. Stanfield Andrew B. Ward Max Crispin Richard T. Wyatt Ian A. Wilson
author_sort	Anita Sarkar
title	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
title_short	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
title_full	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
title_fullStr	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
title_full_unstemmed	Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
title_sort	structure of a cleavage-independent hiv env recapitulates the glycoprotein architecture of the native cleaved trimer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ebe9459afc54000bd784b1509c2346e
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Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

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