Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.

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Autores principales:	Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e3
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spelling	oai:doaj.org-article:5ebeb3f36eeb489b8e165e8571b181e32021-12-02T17:52:38ZAltered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders10.1038/s41467-021-23903-52041-1723https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23903-5https://doaj.org/toc/2041-1723Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.Maria De RisiMichele TufanoFilomena Grazia AlvinoMaria Grazia FerraroGiulia TorrominoYlenia GiganteJlenia MonfregolaElena MarroccoSalvatore PulcranoLea TunisiClaudia LubranoDulce Papy-GarciaYaakov TuchmanAlberto SalleoFrancesca SantoroGian Carlo BellenchiLuigia CristinoAndrea BallabioAlessandro FraldiElvira De LeonibusNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria De Risi Michele Tufano Filomena Grazia Alvino Maria Grazia Ferraro Giulia Torromino Ylenia Gigante Jlenia Monfregola Elena Marrocco Salvatore Pulcrano Lea Tunisi Claudia Lubrano Dulce Papy-Garcia Yaakov Tuchman Alberto Salleo Francesca Santoro Gian Carlo Bellenchi Luigia Cristino Andrea Ballabio Alessandro Fraldi Elvira De Leonibus Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
description	Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of heparan sulfate cause autistic behaviours in mice.
format	article
author	Maria De Risi Michele Tufano Filomena Grazia Alvino Maria Grazia Ferraro Giulia Torromino Ylenia Gigante Jlenia Monfregola Elena Marrocco Salvatore Pulcrano Lea Tunisi Claudia Lubrano Dulce Papy-Garcia Yaakov Tuchman Alberto Salleo Francesca Santoro Gian Carlo Bellenchi Luigia Cristino Andrea Ballabio Alessandro Fraldi Elvira De Leonibus
author_facet	Maria De Risi Michele Tufano Filomena Grazia Alvino Maria Grazia Ferraro Giulia Torromino Ylenia Gigante Jlenia Monfregola Elena Marrocco Salvatore Pulcrano Lea Tunisi Claudia Lubrano Dulce Papy-Garcia Yaakov Tuchman Alberto Salleo Francesca Santoro Gian Carlo Bellenchi Luigia Cristino Andrea Ballabio Alessandro Fraldi Elvira De Leonibus
author_sort	Maria De Risi
title	Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
title_short	Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
title_full	Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
title_fullStr	Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
title_full_unstemmed	Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
title_sort	altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e3
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Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

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