EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN

Abstract. This study has shown that that a common cytokine pool induced in cultured human peripheral blood cells (PBC) supplied by either γ-globulin fraction proteins, copper or zinc cations, or appropriate metal complexes, contains detectable amounts of IL-6 (0.39+0.14 to 2.04+0.16 ng/ml). γ-globul...

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Autores principales:	S. B. Cheknev, I. E. Efremova, A. S. Mezdrokhina, A. A. Babajanz
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	γ-globulin metal complexes il-6 induction production Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5ebfd31ad17a423b91813a2828590d43
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spelling	oai:doaj.org-article:5ebfd31ad17a423b91813a2828590d432021-11-18T08:03:42ZEVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN1563-06252313-741X10.15789/1563-0625-2012-6-483-488https://doaj.org/article/5ebfd31ad17a423b91813a2828590d432014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/543https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. This study has shown that that a common cytokine pool induced in cultured human peripheral blood cells (PBC) supplied by either γ-globulin fraction proteins, copper or zinc cations, or appropriate metal complexes, contains detectable amounts of IL-6 (0.39+0.14 to 2.04+0.16 ng/ml). γ-globulin complexes with zinc or copper ions are able to induce production of IL-6 in amounts differing from those induced by control proteins, or copper and zinc ions used alone. IL-6 production by PBC in presence of γ-globulin/zinc complexes was 1.5 to 2.5-fold higher than with control proteins or single zinc ions at 24, 48 and 72 hrs of observation, whereas IL-6 production by PBC in presence of γ-globulin complexes with copper was higher than with appropriate control proteins or copper ions used alone for 48 and 72 hrs of cell incubation (resp., 1.7 to 2.4 and 2.8 to 4.6-fold increase). Possible role of copper and zinc ions chelated by γ-globulins from the microenvironment and modifying the Fc regions of antibodies, is considered a potential regulatory factor of IL-6 production by human PBC.S. B. CheknevI. E. EfremovaA. S. MezdrokhinaA. A. BabajanzSPb RAACIarticleγ-globulinmetal complexesil-6inductionproductionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 6, Pp 483-488 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	γ-globulin metal complexes il-6 induction production Immunologic diseases. Allergy RC581-607
spellingShingle	γ-globulin metal complexes il-6 induction production Immunologic diseases. Allergy RC581-607 S. B. Cheknev I. E. Efremova A. S. Mezdrokhina A. A. Babajanz EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
description	Abstract. This study has shown that that a common cytokine pool induced in cultured human peripheral blood cells (PBC) supplied by either γ-globulin fraction proteins, copper or zinc cations, or appropriate metal complexes, contains detectable amounts of IL-6 (0.39+0.14 to 2.04+0.16 ng/ml). γ-globulin complexes with zinc or copper ions are able to induce production of IL-6 in amounts differing from those induced by control proteins, or copper and zinc ions used alone. IL-6 production by PBC in presence of γ-globulin/zinc complexes was 1.5 to 2.5-fold higher than with control proteins or single zinc ions at 24, 48 and 72 hrs of observation, whereas IL-6 production by PBC in presence of γ-globulin complexes with copper was higher than with appropriate control proteins or copper ions used alone for 48 and 72 hrs of cell incubation (resp., 1.7 to 2.4 and 2.8 to 4.6-fold increase). Possible role of copper and zinc ions chelated by γ-globulins from the microenvironment and modifying the Fc regions of antibodies, is considered a potential regulatory factor of IL-6 production by human PBC.
format	article
author	S. B. Cheknev I. E. Efremova A. S. Mezdrokhina A. A. Babajanz
author_facet	S. B. Cheknev I. E. Efremova A. S. Mezdrokhina A. A. Babajanz
author_sort	S. B. Cheknev
title	EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
title_short	EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
title_full	EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
title_fullStr	EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
title_full_unstemmed	EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN
title_sort	evaluation of il-6 production by human blood cells incubated with metal complexes of γ-globulin
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5ebfd31ad17a423b91813a2828590d43
work_keys_str_mv	AT sbcheknev evaluationofil6productionbyhumanbloodcellsincubatedwithmetalcomplexesofgglobulin AT ieefremova evaluationofil6productionbyhumanbloodcellsincubatedwithmetalcomplexesofgglobulin AT asmezdrokhina evaluationofil6productionbyhumanbloodcellsincubatedwithmetalcomplexesofgglobulin AT aababajanz evaluationofil6productionbyhumanbloodcellsincubatedwithmetalcomplexesofgglobulin
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EVALUATION OF IL-6 PRODUCTION BY HUMAN BLOOD CELLS INCUBATED WITH METAL COMPLEXES OF Γ-GLOBULIN

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