Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort

Chukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.bed...

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Autores principales:	Iwundu C, Pang D, Pappas Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	maternal education metabolic syndrome risk markers biomedical survey ncds data Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5ec4c4b9a36b47ca8764980a9a78b184
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spelling	oai:doaj.org-article:5ec4c4b9a36b47ca8764980a9a78b1842021-12-02T11:25:32ZChildhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort1178-7007https://doaj.org/article/5ec4c4b9a36b47ca8764980a9a78b1842020-10-01T00:00:00Zhttps://www.dovepress.com/childhood-maternal-school-leaving-age-level-of-education-and-risk-mark-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.beds.ac.ukPurpose: The aim of this study is to investigate the relationship between childhood maternal level of education (CMLE) and changes in anthropometric and laboratory risk markers of metabolic syndrome (MetS) in mid-adulthood using results from the 1958 British Birth Cohort Study.Design: Cohort study.Participants: A total of 9376 study samples consisting of subjects that participated in the biomedical survey of the national child development study (NCDS) carried out between 2002 and 2004 were used for the analysis.Main Outcome Measures: Five risk markers of MetS: (i) HDL-cholesterol (ii) triglyceride (iii) blood pressure (BP) including systolic (SBP) and diastolic (DBP) (iv) waist circumference (WC) and (v) glycated haemoglobin (HbA1c).Methods: The NCDS or the 1958 British birth cohort data deposited in the UK data service by the centre for longitudinal studies were used for analyses. Ordinary least squares regression was used to determine unit changes in the outcome variables given CMLE.Results: The estimates for unadjusted regression analysis of individual risk markers indicated a significant relationship between CMLE and alterations in the five risk markers of MetS (HDL-cholesterol, triglyceride, WC, HbA1c, and BP) in midlife. After adjustment for birth and lifestyle characteristics/health behaviours, the relationship between CMLE and the risk markers was attenuated for HDL-cholesterol, triglycerides, and HbA1c but remained significant for WC 0.70 (95% confidence interval (CI) 0.065– 1.30, p< 0.001) and SBP 1.48 (95% CI 0.48– 2.47 p< 0.001).Conclusion: There was a positive association between lower CMLE and the risk of MetS using the NCDS data. Lifestyle characteristics may be influential determinants of MetS risk in mid-adulthood.Keywords: maternal education, metabolic syndrome, risk markers, biomedical survey, NCDS dataIwundu CPang DPappas YDove Medical Pressarticlematernal educationmetabolic syndromerisk markersbiomedical surveyncds dataSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3761-3771 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	maternal education metabolic syndrome risk markers biomedical survey ncds data Specialties of internal medicine RC581-951
spellingShingle	maternal education metabolic syndrome risk markers biomedical survey ncds data Specialties of internal medicine RC581-951 Iwundu C Pang D Pappas Y Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
description	Chukwuma Iwundu, Dong Pang, Yannis Pappas Institute for Health Research, University of Bedfordshire, Luton, UKCorrespondence: Chukwuma IwunduInstitute for Health Research, University of Bedfordshire, Luton, Bedfordshire LU2 8LE, UKTel +44 1582 743797Fax +44 1582 743918Email Chukwuma.iwundu@study.beds.ac.ukPurpose: The aim of this study is to investigate the relationship between childhood maternal level of education (CMLE) and changes in anthropometric and laboratory risk markers of metabolic syndrome (MetS) in mid-adulthood using results from the 1958 British Birth Cohort Study.Design: Cohort study.Participants: A total of 9376 study samples consisting of subjects that participated in the biomedical survey of the national child development study (NCDS) carried out between 2002 and 2004 were used for the analysis.Main Outcome Measures: Five risk markers of MetS: (i) HDL-cholesterol (ii) triglyceride (iii) blood pressure (BP) including systolic (SBP) and diastolic (DBP) (iv) waist circumference (WC) and (v) glycated haemoglobin (HbA1c).Methods: The NCDS or the 1958 British birth cohort data deposited in the UK data service by the centre for longitudinal studies were used for analyses. Ordinary least squares regression was used to determine unit changes in the outcome variables given CMLE.Results: The estimates for unadjusted regression analysis of individual risk markers indicated a significant relationship between CMLE and alterations in the five risk markers of MetS (HDL-cholesterol, triglyceride, WC, HbA1c, and BP) in midlife. After adjustment for birth and lifestyle characteristics/health behaviours, the relationship between CMLE and the risk markers was attenuated for HDL-cholesterol, triglycerides, and HbA1c but remained significant for WC 0.70 (95% confidence interval (CI) 0.065– 1.30, p< 0.001) and SBP 1.48 (95% CI 0.48– 2.47 p< 0.001).Conclusion: There was a positive association between lower CMLE and the risk of MetS using the NCDS data. Lifestyle characteristics may be influential determinants of MetS risk in mid-adulthood.Keywords: maternal education, metabolic syndrome, risk markers, biomedical survey, NCDS data
format	article
author	Iwundu C Pang D Pappas Y
author_facet	Iwundu C Pang D Pappas Y
author_sort	Iwundu C
title	Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
title_short	Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
title_full	Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
title_fullStr	Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
title_full_unstemmed	Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort
title_sort	childhood maternal school leaving age (level of education) and risk markers of metabolic syndrome in mid-adulthood: results from the 1958 british birth cohort
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5ec4c4b9a36b47ca8764980a9a78b184
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Childhood Maternal School Leaving Age (Level of Education) and Risk Markers of Metabolic Syndrome in Mid-Adulthood: Results from the 1958 British Birth Cohort

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