Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interactions between the cargo and an exosome-localized par...

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Autores principales:	Nambin Yim, Seung-Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, Mohammed R. Shaker, Woong Sun, Ji-Ho Park, Daesoo Kim, Won Do Heo, Chulhee Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ecca384bd0343d7bad8c5a0f51a75de
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spelling	oai:doaj.org-article:5ecca384bd0343d7bad8c5a0f51a75de2021-12-02T14:39:30ZExosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module10.1038/ncomms122772041-1723https://doaj.org/article/5ecca384bd0343d7bad8c5a0f51a75de2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12277https://doaj.org/toc/2041-1723Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.Nambin YimSeung-Wook RyuKyungsun ChoiKwang Ryeol LeeSeunghee LeeHojun ChoiJeongjin KimMohammed R. ShakerWoong SunJi-Ho ParkDaesoo KimWon Do HeoChulhee ChoiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nambin Yim Seung-Wook Ryu Kyungsun Choi Kwang Ryeol Lee Seunghee Lee Hojun Choi Jeongjin Kim Mohammed R. Shaker Woong Sun Ji-Ho Park Daesoo Kim Won Do Heo Chulhee Choi Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
description	Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.
format	article
author	Nambin Yim Seung-Wook Ryu Kyungsun Choi Kwang Ryeol Lee Seunghee Lee Hojun Choi Jeongjin Kim Mohammed R. Shaker Woong Sun Ji-Ho Park Daesoo Kim Won Do Heo Chulhee Choi
author_facet	Nambin Yim Seung-Wook Ryu Kyungsun Choi Kwang Ryeol Lee Seunghee Lee Hojun Choi Jeongjin Kim Mohammed R. Shaker Woong Sun Ji-Ho Park Daesoo Kim Won Do Heo Chulhee Choi
author_sort	Nambin Yim
title	Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
title_short	Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
title_full	Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
title_fullStr	Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
title_full_unstemmed	Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
title_sort	exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5ecca384bd0343d7bad8c5a0f51a75de
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Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

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