Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

Exosomes have been identified as promising vehicles for the in vivodelivery of therapeutic molecules. Here the authors design a system to load protein cargos into exosomes during their biogenesis using optogenetic control of protein-protein interactions between the cargo and an exosome-localized par...

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Auteurs principaux: Nambin Yim, Seung-Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, Mohammed R. Shaker, Woong Sun, Ji-Ho Park, Daesoo Kim, Won Do Heo, Chulhee Choi
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/5ecca384bd0343d7bad8c5a0f51a75de
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