Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells

Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells

Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeder...

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Autores principales: Renpeng Guo, Xiaoying Ye, Jiao Yang, Zhongcheng Zhou, Chenglei Tian, Hua Wang, Haiying Wang, Haifeng Fu, Chun Liu, Ming Zeng, Jun Yang, Lin Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5ecd60b02aa5444a997fd7adbfe402ec
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spelling oai:doaj.org-article:5ecd60b02aa5444a997fd7adbfe402ec2021-12-02T14:41:17ZFeeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells10.1038/s41467-018-05038-22041-1723https://doaj.org/article/5ecd60b02aa5444a997fd7adbfe402ec2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05038-2https://doaj.org/toc/2041-1723Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feedersRenpeng GuoXiaoying YeJiao YangZhongcheng ZhouChenglei TianHua WangHaiying WangHaifeng FuChun LiuMing ZengJun YangLin LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Renpeng Guo
Xiaoying Ye
Jiao Yang
Zhongcheng Zhou
Chenglei Tian
Hua Wang
Haiying Wang
Haifeng Fu
Chun Liu
Ming Zeng
Jun Yang
Lin Liu
Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
description Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeders
format article
author Renpeng Guo
Xiaoying Ye
Jiao Yang
Zhongcheng Zhou
Chenglei Tian
Hua Wang
Haiying Wang
Haifeng Fu
Chun Liu
Ming Zeng
Jun Yang
Lin Liu
author_facet Renpeng Guo
Xiaoying Ye
Jiao Yang
Zhongcheng Zhou
Chenglei Tian
Hua Wang
Haiying Wang
Haifeng Fu
Chun Liu
Ming Zeng
Jun Yang
Lin Liu
author_sort Renpeng Guo
title Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
title_short Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
title_full Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
title_fullStr Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
title_full_unstemmed Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
title_sort feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5ecd60b02aa5444a997fd7adbfe402ec
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AT xiaoyingye feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT jiaoyang feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT zhongchengzhou feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT chengleitian feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT huawang feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT haiyingwang feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT haifengfu feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT chunliu feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT mingzeng feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT junyang feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
AT linliu feedersfacilitatetelomeremaintenanceandchromosomalstabilityofembryonicstemcells
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