A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.

BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profile...

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Autores principales:	Yenny Djuardi, Erliyani Sartono, Heri Wibowo, Taniawati Supali, Maria Yazdanbakhsh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ecd6c72da704aea97d5318d562660ee
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spelling	oai:doaj.org-article:5ecd6c72da704aea97d5318d562660ee2021-11-18T07:36:41ZA longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.1932-620310.1371/journal.pone.0014066https://doaj.org/article/5ecd6c72da704aea97d5318d562660ee2010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21124909/?tool=EBIhttps://doaj.org/toc/1932-6203BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4 years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-α production whereas some alterations in general adaptive immune responses to PHA were observed.Yenny DjuardiErliyani SartonoHeri WibowoTaniawati SupaliMaria YazdanbakhshPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14066 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yenny Djuardi Erliyani Sartono Heri Wibowo Taniawati Supali Maria Yazdanbakhsh A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
description	BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4 years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-α production whereas some alterations in general adaptive immune responses to PHA were observed.
format	article
author	Yenny Djuardi Erliyani Sartono Heri Wibowo Taniawati Supali Maria Yazdanbakhsh
author_facet	Yenny Djuardi Erliyani Sartono Heri Wibowo Taniawati Supali Maria Yazdanbakhsh
author_sort	Yenny Djuardi
title	A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
title_short	A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
title_full	A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
title_fullStr	A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
title_full_unstemmed	A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.
title_sort	longitudinal study of bcg vaccination in early childhood: the development of innate and adaptive immune responses.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/5ecd6c72da704aea97d5318d562660ee
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A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses.

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