Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre-vaccination immune phenotype and vaccination hist...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katharina Wild, Maike Smits, Saskia Killmer, Shirin Strohmeier, Christoph Neumann-Haefelin, Bertram Bengsch, Florian Krammer, Martin Schwemmle, Maike Hofmann, Robert Thimme, Katharina Zoldan, Tobias Boettler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ecdcebcaf7d4d5180dbe8bfd157f337
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5ecdcebcaf7d4d5180dbe8bfd157f337
record_format	dspace
spelling	oai:doaj.org-article:5ecdcebcaf7d4d5180dbe8bfd157f3372021-11-21T12:35:54ZPre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination10.1038/s41467-021-27064-32041-1723https://doaj.org/article/5ecdcebcaf7d4d5180dbe8bfd157f3372021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27064-3https://doaj.org/toc/2041-1723Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre-vaccination immune phenotype and vaccination history of recipients.Katharina WildMaike SmitsSaskia KillmerShirin StrohmeierChristoph Neumann-HaefelinBertram BengschFlorian KrammerMartin SchwemmleMaike HofmannRobert ThimmeKatharina ZoldanTobias BoettlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katharina Wild Maike Smits Saskia Killmer Shirin Strohmeier Christoph Neumann-Haefelin Bertram Bengsch Florian Krammer Martin Schwemmle Maike Hofmann Robert Thimme Katharina Zoldan Tobias Boettler Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
description	Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre-vaccination immune phenotype and vaccination history of recipients.
format	article
author	Katharina Wild Maike Smits Saskia Killmer Shirin Strohmeier Christoph Neumann-Haefelin Bertram Bengsch Florian Krammer Martin Schwemmle Maike Hofmann Robert Thimme Katharina Zoldan Tobias Boettler
author_facet	Katharina Wild Maike Smits Saskia Killmer Shirin Strohmeier Christoph Neumann-Haefelin Bertram Bengsch Florian Krammer Martin Schwemmle Maike Hofmann Robert Thimme Katharina Zoldan Tobias Boettler
author_sort	Katharina Wild
title	Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
title_short	Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
title_full	Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
title_fullStr	Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
title_full_unstemmed	Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination
title_sort	pre-existing immunity and vaccine history determine hemagglutinin-specific cd4 t cell and igg response following seasonal influenza vaccination
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ecdcebcaf7d4d5180dbe8bfd157f337
work_keys_str_mv	AT katharinawild preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT maikesmits preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT saskiakillmer preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT shirinstrohmeier preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT christophneumannhaefelin preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT bertrambengsch preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT floriankrammer preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT martinschwemmle preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT maikehofmann preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT robertthimme preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT katharinazoldan preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination AT tobiasboettler preexistingimmunityandvaccinehistorydeterminehemagglutininspecificcd4tcellandiggresponsefollowingseasonalinfluenzavaccination
_version_	1718418885635473408

Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

Ejemplares similares