Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study

Objective: The study was to examine whether gestational diabetes mellitus (GDM) can be prevented by early trimester lifestyle counseling in a high-risk population. Methods: From September 2012 to January 2013, 1664 pregnancies in the Department of Obstetrics and Gynecology of First Hospital of Pekin...

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Autores principales:	Shuang Wang, Jing-Mei Ma, Hui-Xia Yang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ed0f691a0b741b29c3b6f7c95b74ef6
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spelling	oai:doaj.org-article:5ed0f691a0b741b29c3b6f7c95b74ef62021-12-02T11:52:39ZLifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study2095-882X10.1016/j.cdtm.2015.09.001https://doaj.org/article/5ed0f691a0b741b29c3b6f7c95b74ef62015-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000523https://doaj.org/toc/2095-882XObjective: The study was to examine whether gestational diabetes mellitus (GDM) can be prevented by early trimester lifestyle counseling in a high-risk population. Methods: From September 2012 to January 2013, 1664 pregnancies in the Department of Obstetrics and Gynecology of First Hospital of Peking University were enrolled in the study during their first prenatal care visit before the 8 gestational weeks visit and asked to fill out a questionnaire on GDM risk evaluation. According to the questionnaire and medical records, those with at least one risk factor of GDM were included in the intervention study and randomly allocated to two groups, intervention group and control group. Routine prenatal care was offered, while standardized two-step lifestyle intervention was provided to the intervention group during 6â8 gestational weeks, and at 12â13 gestational weeks, enforcement intervention based on maternal anthropometrics were offered. Both groups were followed until 75Â g oral glucose tolerance test (OGTT) testing at 24â28 gestational weeks. The weight gain after intervention and the prevalence of GDM were used to evaluate the effect. Results: (1) According to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria, the positive rate of GDM for the intervention group was 17.16% (23/134), lower than the control group which was 23.91% (33/138), PÂ =Â 0.168. (2) The weight gain during the first and second trimester for the intervention group was (1.38Â Â±Â 2.34)Â kg and (5.51Â Â±Â 2.18)Â kg, lower than in the control group which was (1.41Â Â±Â 2.58)Â kg and (5.66Â Â±Â 2.25)Â kg, (PÂ =Â 0.905, PÂ =Â 0.567). (3) Positive rate of GDM for those fasting plasma glucose (FPG) â¥5.1Â mmol/L during early pregnancy was 11/36 (30.55%) for the intervention group that was lower than 17/37 (45.95%) for the control group, but the statistical difference was not significant (PÂ =Â 0.076). Conclusion: The positive rate of GDM could be reduced by a certain amount lifestyle intervention from the beginning of pregnancy. More validated effective intervention should be explored in the high-risk pregnant women. Keywords: Gestational diabetes mellitus, Risk factor, Lifestyle interventionShuang WangJing-Mei MaHui-Xia YangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 3, Pp 169-174 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shuang Wang Jing-Mei Ma Hui-Xia Yang Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
description	Objective: The study was to examine whether gestational diabetes mellitus (GDM) can be prevented by early trimester lifestyle counseling in a high-risk population. Methods: From September 2012 to January 2013, 1664 pregnancies in the Department of Obstetrics and Gynecology of First Hospital of Peking University were enrolled in the study during their first prenatal care visit before the 8 gestational weeks visit and asked to fill out a questionnaire on GDM risk evaluation. According to the questionnaire and medical records, those with at least one risk factor of GDM were included in the intervention study and randomly allocated to two groups, intervention group and control group. Routine prenatal care was offered, while standardized two-step lifestyle intervention was provided to the intervention group during 6â8 gestational weeks, and at 12â13 gestational weeks, enforcement intervention based on maternal anthropometrics were offered. Both groups were followed until 75Â g oral glucose tolerance test (OGTT) testing at 24â28 gestational weeks. The weight gain after intervention and the prevalence of GDM were used to evaluate the effect. Results: (1) According to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria, the positive rate of GDM for the intervention group was 17.16% (23/134), lower than the control group which was 23.91% (33/138), PÂ =Â 0.168. (2) The weight gain during the first and second trimester for the intervention group was (1.38Â Â±Â 2.34)Â kg and (5.51Â Â±Â 2.18)Â kg, lower than in the control group which was (1.41Â Â±Â 2.58)Â kg and (5.66Â Â±Â 2.25)Â kg, (PÂ =Â 0.905, PÂ =Â 0.567). (3) Positive rate of GDM for those fasting plasma glucose (FPG) â¥5.1Â mmol/L during early pregnancy was 11/36 (30.55%) for the intervention group that was lower than 17/37 (45.95%) for the control group, but the statistical difference was not significant (PÂ =Â 0.076). Conclusion: The positive rate of GDM could be reduced by a certain amount lifestyle intervention from the beginning of pregnancy. More validated effective intervention should be explored in the high-risk pregnant women. Keywords: Gestational diabetes mellitus, Risk factor, Lifestyle intervention
format	article
author	Shuang Wang Jing-Mei Ma Hui-Xia Yang
author_facet	Shuang Wang Jing-Mei Ma Hui-Xia Yang
author_sort	Shuang Wang
title	Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
title_short	Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
title_full	Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
title_fullStr	Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
title_full_unstemmed	Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study
title_sort	lifestyle intervention for gestational diabetes mellitus prevention: aâ cluster-randomized controlled study
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/5ed0f691a0b741b29c3b6f7c95b74ef6
work_keys_str_mv	AT shuangwang lifestyleinterventionforgestationaldiabetesmellituspreventionaaclusterrandomizedcontrolledstudy AT jingmeima lifestyleinterventionforgestationaldiabetesmellituspreventionaaclusterrandomizedcontrolledstudy AT huixiayang lifestyleinterventionforgestationaldiabetesmellituspreventionaaclusterrandomizedcontrolledstudy
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Lifestyle intervention for gestational diabetes mellitus prevention: AÂ cluster-randomized controlled study

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