Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control

A metabolic block favoring long sweet life A Sake yeast strain deficient in producing the protein building block serine lives longer than other yeast strains, especially when exposed to high glucose. A team led by Carole Linster at the University of Luxembourg found a broad variability of lifespan w...

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Autores principales:	Paul P. Jung, Zhi Zhang, Nicole Paczia, Christian Jaeger, Tomasz Ignac, Patrick May, Carole L. Linster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5ed222660f3542889b160fef174f2ff8
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spelling	oai:doaj.org-article:5ed222660f3542889b160fef174f2ff82021-12-02T16:05:43ZNatural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control10.1038/s41514-018-0022-62056-3973https://doaj.org/article/5ed222660f3542889b160fef174f2ff82018-03-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0022-6https://doaj.org/toc/2056-3973A metabolic block favoring long sweet life A Sake yeast strain deficient in producing the protein building block serine lives longer than other yeast strains, especially when exposed to high glucose. A team led by Carole Linster at the University of Luxembourg found a broad variability of lifespan when analyzing more than fifty Saccharomyces cerevisiae strains isolated from around the world. Combining hundreds of lifespan measurements with genotype data from a progeny obtained by crossing the long-lived Sake strain and a short-lived collection strain, they identified two genes playing a pivotal role in causing the contrasting aging behavior of the parents: RIM15, when glucose was limiting and SER1, when glucose was plenty. RIM15 is part of a signaling cascade also regulating aging in mammals; SER1 revealed that a blockage in serine synthesis reprograms metabolism to favor glucose storage and long life.Paul P. JungZhi ZhangNicole PacziaChristian JaegerTomasz IgnacPatrick MayCarole L. LinsterNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Paul P. Jung Zhi Zhang Nicole Paczia Christian Jaeger Tomasz Ignac Patrick May Carole L. Linster Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
description	A metabolic block favoring long sweet life A Sake yeast strain deficient in producing the protein building block serine lives longer than other yeast strains, especially when exposed to high glucose. A team led by Carole Linster at the University of Luxembourg found a broad variability of lifespan when analyzing more than fifty Saccharomyces cerevisiae strains isolated from around the world. Combining hundreds of lifespan measurements with genotype data from a progeny obtained by crossing the long-lived Sake strain and a short-lived collection strain, they identified two genes playing a pivotal role in causing the contrasting aging behavior of the parents: RIM15, when glucose was limiting and SER1, when glucose was plenty. RIM15 is part of a signaling cascade also regulating aging in mammals; SER1 revealed that a blockage in serine synthesis reprograms metabolism to favor glucose storage and long life.
format	article
author	Paul P. Jung Zhi Zhang Nicole Paczia Christian Jaeger Tomasz Ignac Patrick May Carole L. Linster
author_facet	Paul P. Jung Zhi Zhang Nicole Paczia Christian Jaeger Tomasz Ignac Patrick May Carole L. Linster
author_sort	Paul P. Jung
title	Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
title_short	Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
title_full	Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
title_fullStr	Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
title_full_unstemmed	Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
title_sort	natural variation of chronological aging in the saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ed222660f3542889b160fef174f2ff8
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Natural variation of chronological aging in the Saccharomyces cerevisiae species reveals diet-dependent mechanisms of life span control

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