Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018

Background: Psoriasis Vulgaris is a chronic inflammatory skin disease that affects patients’ quality of life. Methotrexate is the first-line and most effective systemic therapy in psoriasis vulgaris management. Purpose: The aim of this study was to evaluate clinical improvement after methotrexate th...

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Autores principales:	Damayanti Damayanti, Karina Dyahtantri Pratiwi, Wisnu Triadi Nugroho
Formato:	article
Lenguaje:	EN ID
Publicado:	Universitas Airlangga 2021
Materias:	psoriasis vulgaris methotrexate effectiveness adverse effect Public aspects of medicine RA1-1270 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5ed484b63fe349608bf8786821ccb304
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spelling	oai:doaj.org-article:5ed484b63fe349608bf8786821ccb3042021-12-02T12:53:53ZProfile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–20182301-71712541-092X10.20473/jbe.V9I12021.70-78https://doaj.org/article/5ed484b63fe349608bf8786821ccb3042021-01-01T00:00:00Zhttps://e-journal.unair.ac.id/JBE/article/view/15060https://doaj.org/toc/2301-7171https://doaj.org/toc/2541-092XBackground: Psoriasis Vulgaris is a chronic inflammatory skin disease that affects patients’ quality of life. Methotrexate is the first-line and most effective systemic therapy in psoriasis vulgaris management. Purpose: The aim of this study was to evaluate clinical improvement after methotrexate therapy and any adverse effects of methotrexate therapy in psoriasis vulgaris management. Methods: The data for this descriptive, retrospective study were retrieved from the medical records of 22 psoriasis vulgaris patients who were treated with methotrexate therapy between January 2017 and June 2018 in the Child Kemuning Ward (IRNA), Dr. Soetomo General Hospital in Surabaya, East Java. Results: Data for a total of 22 subjects were collected for this study. The majority of the subjects were in the age group 25–59, and the average age was 40.50±17.20. Good clinical improvement (decrease in the body surface area of the lesion) was found in all patients. The adverse effects of methotrexate were evaluated based on the elevation of liver and renal function test levels. An elevation of aspartate aminotransferase levels was found in 11 patients, and an elevation in alanine aminotransferase levels was found in 13 patients. Elevated blood urea nitrogen levels were found in eight patients, and elevated serum creatinine levels were found in four patients. Conclusion: Methotrexate is an effective treatment for severe psoriasis vulgaris management when administered with careful selection and regular monitoring of patients. Application of methotrexate therapy in accordance with the guidelines remains suitable for psoriasis vulgaris management with vigilance regarding methotrexate’s adverse effects.Damayanti DamayantiKarina Dyahtantri PratiwiWisnu Triadi NugrohoUniversitas Airlanggaarticlepsoriasis vulgarismethotrexateeffectivenessadverse effectPublic aspects of medicineRA1-1270Infectious and parasitic diseasesRC109-216ENIDJurnal Berkala Epidemiologi, Vol 9, Iss 1, Pp 70-78 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	psoriasis vulgaris methotrexate effectiveness adverse effect Public aspects of medicine RA1-1270 Infectious and parasitic diseases RC109-216
spellingShingle	psoriasis vulgaris methotrexate effectiveness adverse effect Public aspects of medicine RA1-1270 Infectious and parasitic diseases RC109-216 Damayanti Damayanti Karina Dyahtantri Pratiwi Wisnu Triadi Nugroho Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
description	Background: Psoriasis Vulgaris is a chronic inflammatory skin disease that affects patients’ quality of life. Methotrexate is the first-line and most effective systemic therapy in psoriasis vulgaris management. Purpose: The aim of this study was to evaluate clinical improvement after methotrexate therapy and any adverse effects of methotrexate therapy in psoriasis vulgaris management. Methods: The data for this descriptive, retrospective study were retrieved from the medical records of 22 psoriasis vulgaris patients who were treated with methotrexate therapy between January 2017 and June 2018 in the Child Kemuning Ward (IRNA), Dr. Soetomo General Hospital in Surabaya, East Java. Results: Data for a total of 22 subjects were collected for this study. The majority of the subjects were in the age group 25–59, and the average age was 40.50±17.20. Good clinical improvement (decrease in the body surface area of the lesion) was found in all patients. The adverse effects of methotrexate were evaluated based on the elevation of liver and renal function test levels. An elevation of aspartate aminotransferase levels was found in 11 patients, and an elevation in alanine aminotransferase levels was found in 13 patients. Elevated blood urea nitrogen levels were found in eight patients, and elevated serum creatinine levels were found in four patients. Conclusion: Methotrexate is an effective treatment for severe psoriasis vulgaris management when administered with careful selection and regular monitoring of patients. Application of methotrexate therapy in accordance with the guidelines remains suitable for psoriasis vulgaris management with vigilance regarding methotrexate’s adverse effects.
format	article
author	Damayanti Damayanti Karina Dyahtantri Pratiwi Wisnu Triadi Nugroho
author_facet	Damayanti Damayanti Karina Dyahtantri Pratiwi Wisnu Triadi Nugroho
author_sort	Damayanti Damayanti
title	Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
title_short	Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
title_full	Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
title_fullStr	Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
title_full_unstemmed	Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018
title_sort	profile of psoriasis vulgaris patients treated with methotrexate at dr. soetomo hospital, surabaya, 2017–2018
publisher	Universitas Airlangga
publishDate	2021
url	https://doaj.org/article/5ed484b63fe349608bf8786821ccb304
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Profile of Psoriasis Vulgaris Patients Treated with Methotrexate at Dr. Soetomo Hospital, Surabaya, 2017–2018

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