Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

Skeletal muscle plays a key role in regulating systemic glucose and metabolic homeostasis. Here, the authors show that the catalytic activity of Vav2, an activator of Rho GTPases, modulates those processes by favoring the responsiveness of this tissue to insulin and related factors.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sonia Rodríguez-Fdez, L. Francisco Lorenzo-Martín, Isabel Fernández-Pisonero, Begoña Porteiro, Christelle Veyrat-Durebex, Daniel Beiroa, Omar Al-Massadi, Antonio Abad, Carlos Diéguez, Roberto Coppari, Rubén Nogueiras, Xosé R. Bustelo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5edbd9861e1747dd8edfd43d21bc579c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5edbd9861e1747dd8edfd43d21bc579c
record_format	dspace
spelling	oai:doaj.org-article:5edbd9861e1747dd8edfd43d21bc579c2021-12-02T15:39:24ZVav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis10.1038/s41467-020-19489-z2041-1723https://doaj.org/article/5edbd9861e1747dd8edfd43d21bc579c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19489-zhttps://doaj.org/toc/2041-1723Skeletal muscle plays a key role in regulating systemic glucose and metabolic homeostasis. Here, the authors show that the catalytic activity of Vav2, an activator of Rho GTPases, modulates those processes by favoring the responsiveness of this tissue to insulin and related factors.Sonia Rodríguez-FdezL. Francisco Lorenzo-MartínIsabel Fernández-PisoneroBegoña PorteiroChristelle Veyrat-DurebexDaniel BeiroaOmar Al-MassadiAntonio AbadCarlos DiéguezRoberto CoppariRubén NogueirasXosé R. BusteloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-26 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sonia Rodríguez-Fdez L. Francisco Lorenzo-Martín Isabel Fernández-Pisonero Begoña Porteiro Christelle Veyrat-Durebex Daniel Beiroa Omar Al-Massadi Antonio Abad Carlos Diéguez Roberto Coppari Rubén Nogueiras Xosé R. Bustelo Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
description	Skeletal muscle plays a key role in regulating systemic glucose and metabolic homeostasis. Here, the authors show that the catalytic activity of Vav2, an activator of Rho GTPases, modulates those processes by favoring the responsiveness of this tissue to insulin and related factors.
format	article
author	Sonia Rodríguez-Fdez L. Francisco Lorenzo-Martín Isabel Fernández-Pisonero Begoña Porteiro Christelle Veyrat-Durebex Daniel Beiroa Omar Al-Massadi Antonio Abad Carlos Diéguez Roberto Coppari Rubén Nogueiras Xosé R. Bustelo
author_facet	Sonia Rodríguez-Fdez L. Francisco Lorenzo-Martín Isabel Fernández-Pisonero Begoña Porteiro Christelle Veyrat-Durebex Daniel Beiroa Omar Al-Massadi Antonio Abad Carlos Diéguez Roberto Coppari Rubén Nogueiras Xosé R. Bustelo
author_sort	Sonia Rodríguez-Fdez
title	Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
title_short	Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
title_full	Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
title_fullStr	Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
title_full_unstemmed	Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
title_sort	vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5edbd9861e1747dd8edfd43d21bc579c
work_keys_str_mv	AT soniarodriguezfdez vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT lfranciscolorenzomartin vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT isabelfernandezpisonero vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT begonaporteiro vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT christelleveyratdurebex vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT danielbeiroa vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT omaralmassadi vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT antonioabad vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT carlosdieguez vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT robertocoppari vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT rubennogueiras vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis AT xoserbustelo vav2catalysisdependentpathwayscontributetoskeletalmusclegrowthandmetabolichomeostasis
_version_	1718385933283229696

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

Ejemplares similares