The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and RO...
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Nature Portfolio
2021
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oai:doaj.org-article:5ede68f3d2b2430db4de9c5749801c0f2021-12-02T13:30:14ZThe mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction10.1038/s41467-021-21178-42041-1723https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21178-4https://doaj.org/toc/2041-1723The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function.Fan JiangKunlun YinKun WuMingmin ZhangShiqiang WangHeping ChengZhou ZhouBailong XiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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Science Q Fan Jiang Kunlun Yin Kun Wu Mingmin Zhang Shiqiang Wang Heping Cheng Zhou Zhou Bailong Xiao The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
description |
The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function. |
format |
article |
author |
Fan Jiang Kunlun Yin Kun Wu Mingmin Zhang Shiqiang Wang Heping Cheng Zhou Zhou Bailong Xiao |
author_facet |
Fan Jiang Kunlun Yin Kun Wu Mingmin Zhang Shiqiang Wang Heping Cheng Zhou Zhou Bailong Xiao |
author_sort |
Fan Jiang |
title |
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
title_short |
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
title_full |
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
title_fullStr |
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
title_full_unstemmed |
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction |
title_sort |
mechanosensitive piezo1 channel mediates heart mechano-chemo transduction |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f |
work_keys_str_mv |
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1718392917710602240 |