The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction

The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and RO...

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Autores principales: Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f
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spelling oai:doaj.org-article:5ede68f3d2b2430db4de9c5749801c0f2021-12-02T13:30:14ZThe mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction10.1038/s41467-021-21178-42041-1723https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21178-4https://doaj.org/toc/2041-1723The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function.Fan JiangKunlun YinKun WuMingmin ZhangShiqiang WangHeping ChengZhou ZhouBailong XiaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
description The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mechanical stretch of cardiomyocytes into Ca2+ and ROS signaling and consequently maintaining normal heart function.
format article
author Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
author_facet Fan Jiang
Kunlun Yin
Kun Wu
Mingmin Zhang
Shiqiang Wang
Heping Cheng
Zhou Zhou
Bailong Xiao
author_sort Fan Jiang
title The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_short The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_full The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_fullStr The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_full_unstemmed The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
title_sort mechanosensitive piezo1 channel mediates heart mechano-chemo transduction
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f
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