Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy
Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The ris...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:5ee18e77d06b48f1a1d7beac1123b87d2021-11-17T05:37:29ZMean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy2297-055X10.3389/fcvm.2021.758635https://doaj.org/article/5ee18e77d06b48f1a1d7beac1123b87d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.758635/fullhttps://doaj.org/toc/2297-055XBackground: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The risk stratification of VA remains complex and LGE is present in the majority of HCM patients. This study was conducted to determine whether the scar heterogeneity from LGE-derived entropy is associated with the VAs in HCM patients.Materials and Methods: Sixty-eight HCM patients with scarring were retrospectively enrolled and divided into VA (31 patients) and non-VA (37 patients) groups. The left ventricular ejection fraction (LVEF) and percentage of the LGE (% LGE) were evaluated. The scar heterogeneity was quantified by the entropy within the scar and left ventricular (LV) myocardium.Results: Multivariate analyses showed that a higher scar [hazard ratio (HR) 2.682; 95% CI: 1.022–7.037; p = 0.039] was independently associated with VA, after the adjustment for the LVEF, %LGE, LV maximal wall thickness (MWT), and left atrium (LA) diameter.Conclusion: Scar entropy and %LGE are both independent risk indicators of VA. A high scar entropy may indicate an arrhythmogenic scar, an identification of which may have value for the clinical status assessment of VAs in HCM patients.Yang YeYang YeZhongPing JiWenli ZhouCailing PuYa LiYa LiChengqin ZhouXiuhua HuChao ChenYaxun SunYaxun SunQi HuangWenjuan ZhangYu'e QianHong RenFeidan YuChenyang JiangChenyang JiangYankai MaoBei WangJoão B. AugustoJoão B. AugustoJoão B. AugustoDongwu LaiDongwu LaiHongjie HuGuo-sheng FuGuo-sheng FuFrontiers Media S.A.articlehypertrophic cardiomyopathyventricular arrhythmiasscar entropycardiac magnetic resonancelate gadolinium enhancementDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021) |
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EN |
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hypertrophic cardiomyopathy ventricular arrhythmias scar entropy cardiac magnetic resonance late gadolinium enhancement Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
hypertrophic cardiomyopathy ventricular arrhythmias scar entropy cardiac magnetic resonance late gadolinium enhancement Diseases of the circulatory (Cardiovascular) system RC666-701 Yang Ye Yang Ye ZhongPing Ji Wenli Zhou Cailing Pu Ya Li Ya Li Chengqin Zhou Xiuhua Hu Chao Chen Yaxun Sun Yaxun Sun Qi Huang Wenjuan Zhang Yu'e Qian Hong Ren Feidan Yu Chenyang Jiang Chenyang Jiang Yankai Mao Bei Wang João B. Augusto João B. Augusto João B. Augusto Dongwu Lai Dongwu Lai Hongjie Hu Guo-sheng Fu Guo-sheng Fu Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| description |
Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The risk stratification of VA remains complex and LGE is present in the majority of HCM patients. This study was conducted to determine whether the scar heterogeneity from LGE-derived entropy is associated with the VAs in HCM patients.Materials and Methods: Sixty-eight HCM patients with scarring were retrospectively enrolled and divided into VA (31 patients) and non-VA (37 patients) groups. The left ventricular ejection fraction (LVEF) and percentage of the LGE (% LGE) were evaluated. The scar heterogeneity was quantified by the entropy within the scar and left ventricular (LV) myocardium.Results: Multivariate analyses showed that a higher scar [hazard ratio (HR) 2.682; 95% CI: 1.022–7.037; p = 0.039] was independently associated with VA, after the adjustment for the LVEF, %LGE, LV maximal wall thickness (MWT), and left atrium (LA) diameter.Conclusion: Scar entropy and %LGE are both independent risk indicators of VA. A high scar entropy may indicate an arrhythmogenic scar, an identification of which may have value for the clinical status assessment of VAs in HCM patients. |
| format |
article |
| author |
Yang Ye Yang Ye ZhongPing Ji Wenli Zhou Cailing Pu Ya Li Ya Li Chengqin Zhou Xiuhua Hu Chao Chen Yaxun Sun Yaxun Sun Qi Huang Wenjuan Zhang Yu'e Qian Hong Ren Feidan Yu Chenyang Jiang Chenyang Jiang Yankai Mao Bei Wang João B. Augusto João B. Augusto João B. Augusto Dongwu Lai Dongwu Lai Hongjie Hu Guo-sheng Fu Guo-sheng Fu |
| author_facet |
Yang Ye Yang Ye ZhongPing Ji Wenli Zhou Cailing Pu Ya Li Ya Li Chengqin Zhou Xiuhua Hu Chao Chen Yaxun Sun Yaxun Sun Qi Huang Wenjuan Zhang Yu'e Qian Hong Ren Feidan Yu Chenyang Jiang Chenyang Jiang Yankai Mao Bei Wang João B. Augusto João B. Augusto João B. Augusto Dongwu Lai Dongwu Lai Hongjie Hu Guo-sheng Fu Guo-sheng Fu |
| author_sort |
Yang Ye |
| title |
Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| title_short |
Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| title_full |
Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| title_fullStr |
Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| title_full_unstemmed |
Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy |
| title_sort |
mean scar entropy by late gadolinium enhancement cardiac magnetic resonance is associated with ventricular arrhythmias events in hypertrophic cardiomyopathy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/5ee18e77d06b48f1a1d7beac1123b87d |
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