A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters
Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro.
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Nature Portfolio
2021
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oai:doaj.org-article:5eea106784d445baadd6d500eadbdebc2021-11-08T11:12:23ZA live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters10.1038/s41467-021-26506-22041-1723https://doaj.org/article/5eea106784d445baadd6d500eadbdebc2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26506-2https://doaj.org/toc/2041-1723Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro.Phanramphoei N. FrantzAleksandr BarinovClaude RuffiéChantal CombredetValérie NajburgGuilherme Dias de MeloFlorence LarrousLauriane KergoatSamaporn TeeravechyanAnan JongkaewwattanaEmmanuelle Billon-DenisJean-Nicolas TournierMatthieu ProtLaurine LevillayerLaurine ConquetXavier MontagutelliMagali TichitDavid HardyPriyanka FernandesHélène Strick-MarchandJames Di SantoEtienne Simon-LorièreHervé BourhyFrédéric TangyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Phanramphoei N. Frantz Aleksandr Barinov Claude Ruffié Chantal Combredet Valérie Najburg Guilherme Dias de Melo Florence Larrous Lauriane Kergoat Samaporn Teeravechyan Anan Jongkaewwattana Emmanuelle Billon-Denis Jean-Nicolas Tournier Matthieu Prot Laurine Levillayer Laurine Conquet Xavier Montagutelli Magali Tichit David Hardy Priyanka Fernandes Hélène Strick-Marchand James Di Santo Etienne Simon-Lorière Hervé Bourhy Frédéric Tangy A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| description |
Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro. |
| format |
article |
| author |
Phanramphoei N. Frantz Aleksandr Barinov Claude Ruffié Chantal Combredet Valérie Najburg Guilherme Dias de Melo Florence Larrous Lauriane Kergoat Samaporn Teeravechyan Anan Jongkaewwattana Emmanuelle Billon-Denis Jean-Nicolas Tournier Matthieu Prot Laurine Levillayer Laurine Conquet Xavier Montagutelli Magali Tichit David Hardy Priyanka Fernandes Hélène Strick-Marchand James Di Santo Etienne Simon-Lorière Hervé Bourhy Frédéric Tangy |
| author_facet |
Phanramphoei N. Frantz Aleksandr Barinov Claude Ruffié Chantal Combredet Valérie Najburg Guilherme Dias de Melo Florence Larrous Lauriane Kergoat Samaporn Teeravechyan Anan Jongkaewwattana Emmanuelle Billon-Denis Jean-Nicolas Tournier Matthieu Prot Laurine Levillayer Laurine Conquet Xavier Montagutelli Magali Tichit David Hardy Priyanka Fernandes Hélène Strick-Marchand James Di Santo Etienne Simon-Lorière Hervé Bourhy Frédéric Tangy |
| author_sort |
Phanramphoei N. Frantz |
| title |
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| title_short |
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| title_full |
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| title_fullStr |
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| title_full_unstemmed |
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters |
| title_sort |
live measles-vectored covid-19 vaccine induces strong immunity and protection from sars-cov-2 challenge in mice and hamsters |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5eea106784d445baadd6d500eadbdebc |
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