RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling the expression of splicing factors.

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Detalles Bibliográficos
Autores principales:	Vasily V. Grinev, Farnaz Barneh, Ilya M. Ilyushonak, Sirintra Nakjang, Job Smink, Anita van Oort, Richard Clough, Michael Seyani, Hesta McNeill, Mojgan Reza, Natalia Martinez-Soria, Salam A. Assi, Tatsiana V. Ramanouskaya, Constanze Bonifer, Olaf Heidenreich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5eec00d838bf48d7a8a72e936547e1a8
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spelling	oai:doaj.org-article:5eec00d838bf48d7a8a72e936547e1a82021-12-02T10:49:32ZRUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia10.1038/s41467-020-20848-z2041-1723https://doaj.org/article/5eec00d838bf48d7a8a72e936547e1a82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20848-zhttps://doaj.org/toc/2041-1723The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling the expression of splicing factors.Vasily V. GrinevFarnaz BarnehIlya M. IlyushonakSirintra NakjangJob SminkAnita van OortRichard CloughMichael SeyaniHesta McNeillMojgan RezaNatalia Martinez-SoriaSalam A. AssiTatsiana V. RamanouskayaConstanze BoniferOlaf HeidenreichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vasily V. Grinev Farnaz Barneh Ilya M. Ilyushonak Sirintra Nakjang Job Smink Anita van Oort Richard Clough Michael Seyani Hesta McNeill Mojgan Reza Natalia Martinez-Soria Salam A. Assi Tatsiana V. Ramanouskaya Constanze Bonifer Olaf Heidenreich RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
description	The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling the expression of splicing factors.
format	article
author	Vasily V. Grinev Farnaz Barneh Ilya M. Ilyushonak Sirintra Nakjang Job Smink Anita van Oort Richard Clough Michael Seyani Hesta McNeill Mojgan Reza Natalia Martinez-Soria Salam A. Assi Tatsiana V. Ramanouskaya Constanze Bonifer Olaf Heidenreich
author_facet	Vasily V. Grinev Farnaz Barneh Ilya M. Ilyushonak Sirintra Nakjang Job Smink Anita van Oort Richard Clough Michael Seyani Hesta McNeill Mojgan Reza Natalia Martinez-Soria Salam A. Assi Tatsiana V. Ramanouskaya Constanze Bonifer Olaf Heidenreich
author_sort	Vasily V. Grinev
title	RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
title_short	RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
title_full	RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
title_fullStr	RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
title_full_unstemmed	RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
title_sort	runx1/runx1t1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5eec00d838bf48d7a8a72e936547e1a8
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RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

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