A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress

Abstract The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan....

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Autores principales:	Yi-Shuan Sheen, Yi-Hua Liao, Ming-Hsien Lin, Jau-Shiuh Chen, Jau-Yu Liau, Yu-Ju Tseng, Chih-Hung Lee, Yih-Leong Chang, Chia-Yu Chu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5eec49f7729846e2b5624953dbee906d
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spelling	oai:doaj.org-article:5eec49f7729846e2b5624953dbee906d2021-12-02T12:31:47ZA clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress10.1038/s41598-017-05809-92045-2322https://doaj.org/article/5eec49f7729846e2b5624953dbee906d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05809-9https://doaj.org/toc/2045-2322Abstract The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan. The male-to-female ratio of the patients in question was 1:1.28, and the mean age at diagnosis was 68 years. We examined whether melanomas which developed in different areas of the patients’ soles differed in their associations with various clinicopathological characteristics and survival. Testing by goodness of fit indicated that stress-bearing areas were significantly more conducive to the generation of melanomas than non-stress-bearing areas (P < 0.0001). More specifically, compared to the arch, the rear of the foot and front of the foot were significantly more conducive to the generation of melanomas (P < 0.0001 and P < 0.0001, respectively). The distribution pattern was not associated with differences in age, gender, right/left foot involvement, ulceration, mitosis, lymph node metastasis, tumor thickness, or stage. The overall, distant metastasis-free, and recurrence-free survival rates did not differ significantly between the stress-bearing and non-stress-bearing areas. Furthermore, while acral melanomas tended to develop on stress-bearing areas, the distribution pattern was not associated with the prognostic index or survival.Yi-Shuan SheenYi-Hua LiaoMing-Hsien LinJau-Shiuh ChenJau-Yu LiauYu-Ju TsengChih-Hung LeeYih-Leong ChangChia-Yu ChuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Shuan Sheen Yi-Hua Liao Ming-Hsien Lin Jau-Shiuh Chen Jau-Yu Liau Yu-Ju Tseng Chih-Hung Lee Yih-Leong Chang Chia-Yu Chu A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
description	Abstract The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan. The male-to-female ratio of the patients in question was 1:1.28, and the mean age at diagnosis was 68 years. We examined whether melanomas which developed in different areas of the patients’ soles differed in their associations with various clinicopathological characteristics and survival. Testing by goodness of fit indicated that stress-bearing areas were significantly more conducive to the generation of melanomas than non-stress-bearing areas (P < 0.0001). More specifically, compared to the arch, the rear of the foot and front of the foot were significantly more conducive to the generation of melanomas (P < 0.0001 and P < 0.0001, respectively). The distribution pattern was not associated with differences in age, gender, right/left foot involvement, ulceration, mitosis, lymph node metastasis, tumor thickness, or stage. The overall, distant metastasis-free, and recurrence-free survival rates did not differ significantly between the stress-bearing and non-stress-bearing areas. Furthermore, while acral melanomas tended to develop on stress-bearing areas, the distribution pattern was not associated with the prognostic index or survival.
format	article
author	Yi-Shuan Sheen Yi-Hua Liao Ming-Hsien Lin Jau-Shiuh Chen Jau-Yu Liau Yu-Ju Tseng Chih-Hung Lee Yih-Leong Chang Chia-Yu Chu
author_facet	Yi-Shuan Sheen Yi-Hua Liao Ming-Hsien Lin Jau-Shiuh Chen Jau-Yu Liau Yu-Ju Tseng Chih-Hung Lee Yih-Leong Chang Chia-Yu Chu
author_sort	Yi-Shuan Sheen
title	A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
title_short	A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
title_full	A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
title_fullStr	A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
title_full_unstemmed	A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
title_sort	clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5eec49f7729846e2b5624953dbee906d
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A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress

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